{"id":"W2143154997","doi":"10.1093/genetics/163.4.1287","title":"Mode of Selection and Experimental Evolution of Antifungal Drug Resistance in <i>Saccharomyces cerevisiae</i>","year":2003,"lang":"en","type":"article","venue":"Genetics","topic":"Fungal and yeast genetics research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":154,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Biology; Saccharomyces cerevisiae; Genetics; Antifungal drug; Selection (genetic algorithm); Antifungal; Drug resistance; Drug; Experimental evolution; Mutation; Computational biology; Microbiology; Gene; Pharmacology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007701797,0.0004489027,0.0004203668,0.000358873,0.0003617457,0.0006134383,0.0007498665,0.0004676438,0.0009255189],"category_scores_gemma":[0.0006302149,0.0003604017,0.0003532745,0.0003442019,0.0003395754,0.0001820254,0.0005955157,0.001101614,0.0002666466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006843917,"about_ca_system_score_gemma":0.0003689764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002802241,"about_ca_topic_score_gemma":0.004003131,"domain_scores_codex":[0.9987687,0.0003885668,0.0001886904,0.0003012228,0.0002533507,0.00009941113],"domain_scores_gemma":[0.999243,0.0002548995,0.0001429328,0.0001662346,0.00008747276,0.0001055422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004684432,0.0002355268,0.002662424,0.00003319685,0.00002493424,0.00004188375,0.00005658549,0.0003274622,0.9927533,0.0001069306,0.00008411962,0.003205096],"study_design_scores_gemma":[0.0001798066,0.00363489,0.03150445,0.00001741942,0.00009218881,0.0004236585,0.0001122866,0.004109681,0.9561179,0.0001274033,0.003603577,0.00007681676],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942957,0.0003546336,0.003330614,0.0001069476,0.00002292419,0.0001776846,0.0006263108,0.00006034187,0.001024912],"genre_scores_gemma":[0.9836174,0.0005485648,0.01220481,0.0002235147,0.00001813669,0.0004228073,0.00120148,0.00009376508,0.001669547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002802241,"threshold_uncertainty_score":0.005571902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007036544425089377,"score_gpt":0.2651911717346101,"score_spread":0.2581546273095207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}