{"id":"W2143227538","doi":"10.1093/bioinformatics/btq637","title":"Differential effects of chromatin regulators and transcription factors on gene regulation: a nucleosomal perspective","year":2010,"lang":"en","type":"article","venue":"Bioinformatics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Nucleosome; Chromatin; Biology; Gene; Transcription factor; Promoter; Transcriptional regulation; Genetics; Regulation of gene expression; Saccharomyces cerevisiae; Computational biology; Transcription (linguistics); Histone; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003251347,0.0002599013,0.0003916863,0.0004491242,0.000193038,0.0005602028,0.0003380526,0.0002275021,0.002341862],"category_scores_gemma":[0.0004338422,0.0001243494,0.0002173568,0.0009758929,0.0003616069,0.0005407705,0.0003903839,0.0003211517,0.0004466175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004618636,"about_ca_system_score_gemma":0.0001891028,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002123358,"about_ca_topic_score_gemma":0.002526975,"domain_scores_codex":[0.9998516,0.00002739742,0.000007963421,0.00006701746,0.0000292344,0.00001676695],"domain_scores_gemma":[0.9997811,0.0000847362,0.00003619982,0.00003125236,0.00003199733,0.00003476986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009314742,0.00005113505,0.02742524,0.001612531,0.0001167581,0.0003995936,0.0003785582,0.003704841,0.8444449,0.02660575,0.00175008,0.09257909],"study_design_scores_gemma":[0.00008782173,0.0004989048,0.3409105,0.0003043032,0.0004848615,0.002191179,0.0007480168,0.02725979,0.471873,0.05695057,0.09857108,0.0001199469],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6727327,0.06163088,0.2236156,0.002625512,0.0002692311,0.00007589298,0.008138251,0.001325667,0.02958629],"genre_scores_gemma":[0.9251448,0.01301301,0.05277019,0.0007138244,0.00009917499,0.0000455653,0.003949272,0.0001747838,0.004089348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002341862,"threshold_uncertainty_score":0.007834315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00345497514533326,"score_gpt":0.1960566982394446,"score_spread":0.1926017230941113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}