{"id":"W2143265268","doi":"10.4049/jimmunol.1000386","title":"Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; CTL*; CD8; Biology; T cell; Cell biology; T-cell receptor; Fas ligand; MHC class I; Major histocompatibility complex; Molecular biology; Antigen; Immune system; Chemistry; Immunology; Apoptosis; In vitro; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006408375,0.0001623865,0.0003120427,0.0001184385,0.00007374729,0.000009777938,0.0002577186,0.0002426591,0.00001850417],"category_scores_gemma":[0.0003537414,0.000131264,0.000110943,0.0001261627,0.0004190129,0.0000232993,0.0001479476,0.0003042434,0.000004807484],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001663892,"about_ca_system_score_gemma":0.0001023681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001260998,"about_ca_topic_score_gemma":0.00002007815,"domain_scores_codex":[0.9984942,0.0003355473,0.0006268156,0.0001561491,0.0001686079,0.0002186482],"domain_scores_gemma":[0.9984775,0.000207332,0.0006197144,0.0003473286,0.0002828294,0.00006525829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001276792,0.0001285231,0.0006069167,0.00003901388,0.00007478667,0.00000875871,0.000490881,0.00005352176,0.9968971,0.00004208511,0.0001125061,0.0002691121],"study_design_scores_gemma":[0.0008669299,0.0008755074,0.007144919,0.00005573232,0.00008323471,0.0001996398,0.0003203189,0.00001717783,0.9897514,0.0003234113,0.0002374934,0.0001242232],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964803,0.001420539,0.001365344,0.0002198611,0.0001862655,0.0001992079,0.00002274448,0.000004484662,0.0001012108],"genre_scores_gemma":[0.9980283,0.000451448,0.001158622,0.00007790066,0.0001119127,0.000002808925,0.0000107885,0.00002135336,0.0001369028],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00714569,"threshold_uncertainty_score":0.535279,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112865099814393,"score_gpt":0.2497836849657304,"score_spread":0.2386550339675865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}