{"id":"W2143265268","doi":"10.4049/jimmunol.1000386","title":"Dendritic Cells Recruit T Cell Exosomes via Exosomal LFA-1 Leading to Inhibition of CD8+ CTL Responses through Downregulation of Peptide/MHC Class I and Fas Ligand-Mediated Cytotoxicity","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":129,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Canadian Institutes of Health Research","keywords":"Cytotoxic T cell; CTL*; CD8; Biology; T cell; Cell biology; T-cell receptor; Fas ligand; MHC class I; Major histocompatibility complex; Molecular biology; Antigen; Immune system; Chemistry; Immunology; Apoptosis; In vitro; Programmed cell death; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001164337,0.000296884,0.0003076342,0.0001022983,0.00008198779,0.0003092704,0.0000969594,0.0002621851,0.0006066479],"category_scores_gemma":[0.0001302359,0.0001153988,0.0002440212,0.00007626572,0.0001374385,0.0002261839,0.0002263044,0.0005496565,0.0003199171],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001475619,"about_ca_system_score_gemma":0.0001699322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006690511,"about_ca_topic_score_gemma":0.0000881472,"domain_scores_codex":[0.9998478,0.00002736238,0.00001939798,0.0000312908,0.00002828485,0.00004587298],"domain_scores_gemma":[0.999936,0.00001386383,0.00001734386,0.00000833758,0.000009091344,0.00001530839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001171652,0.00003418899,0.0002124909,0.00005763213,0.0000045189,0.00004895324,0.00001479386,0.00005322933,0.9974793,0.00006668359,0.00005187582,0.001859202],"study_design_scores_gemma":[0.00006688489,0.0003896336,0.002563074,0.00001009887,0.00002403513,0.0002586557,0.00003324302,0.001044868,0.9917761,0.00008805605,0.003741961,0.000003438012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909064,0.002270914,0.005185633,0.0001683869,0.00006200808,0.00004879455,0.0001652872,0.00007401372,0.001118494],"genre_scores_gemma":[0.9941103,0.001406263,0.002211773,0.0001191827,0.00003381218,0.00007605377,0.0002489995,0.00001548407,0.00177808],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006066479,"threshold_uncertainty_score":0.002029479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112865099814393,"score_gpt":0.2497836849657304,"score_spread":0.2386550339675865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}