{"id":"W2143278579","doi":"10.1128/aac.00787-10","title":"Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Protease inhibitor (pharmacology); ADME; Proteases; Biology; Protease; Hepatitis C virus; Pharmacology; In vitro; Chemistry; Biochemistry; Enzyme; Virus; Virology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006978369,0.001112437,0.0008371171,0.0005917766,0.0002982483,0.0005571399,0.0006692864,0.0006337956,0.003500957],"category_scores_gemma":[0.0005127586,0.0003425327,0.0005377152,0.0005234937,0.0003227601,0.0004449206,0.0001920593,0.001784768,0.000914222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005930809,"about_ca_system_score_gemma":0.001085244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001537213,"about_ca_topic_score_gemma":0.00344822,"domain_scores_codex":[0.9998172,0.00005234279,0.00001128315,0.00002811896,0.00004219795,0.00004886782],"domain_scores_gemma":[0.9996978,0.00003454391,0.0000728971,0.0000184669,0.00005938238,0.000116905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02024355,0.02512206,0.001687148,0.001378486,0.0006403739,0.000542976,0.0002632262,0.007570041,0.837036,0.001225872,0.01002859,0.09426164],"study_design_scores_gemma":[0.01089475,0.4590822,0.01641355,0.000161825,0.001262083,0.002357956,0.0001881561,0.00853523,0.4257224,0.0008086814,0.07445487,0.0001183436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.947203,0.01847808,0.01253985,0.0006524216,0.0002719644,0.003267082,0.005244933,0.000455135,0.01188756],"genre_scores_gemma":[0.9660932,0.01269373,0.004651258,0.0005316191,0.00008047221,0.00135389,0.007378872,0.00008324844,0.007133599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003500957,"threshold_uncertainty_score":0.0117119,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952108940189791,"score_gpt":0.3045564591308927,"score_spread":0.2850353697289948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}