{"id":"W2143278579","doi":"10.1128/aac.00787-10","title":"Preclinical Characterization of BI 201335, a C-Terminal Carboxylic Acid Inhibitor of the Hepatitis C Virus NS3-NS4A Protease","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"NS3; Protease inhibitor (pharmacology); ADME; Proteases; Biology; Protease; Hepatitis C virus; Pharmacology; In vitro; Chemistry; Biochemistry; Enzyme; Virus; Virology; Viral load","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001888812,0.000149303,0.0003368435,0.00007176986,0.00006517968,0.00001791619,0.0001491235,0.000166403,0.0004657853],"category_scores_gemma":[0.00006986478,0.0001058699,0.0001252615,0.0001677738,0.0003085511,0.00007910506,0.00006695656,0.0003008307,0.000006910058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001220919,"about_ca_system_score_gemma":0.000142838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005806682,"about_ca_topic_score_gemma":0.0001290388,"domain_scores_codex":[0.9987886,0.00006139134,0.0004232133,0.0002427737,0.0002708299,0.0002131997],"domain_scores_gemma":[0.9991639,0.00001884884,0.0002034249,0.0003500956,0.000154359,0.0001094237],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001970796,0.0002950311,0.2363806,0.0001169585,0.0000409788,0.000005066928,0.0002131719,1.347027e-8,0.743301,0.000004722944,0.000792456,0.01865292],"study_design_scores_gemma":[0.001261083,0.0001702963,0.3976319,0.0001263143,0.00002285822,0.00001473613,0.000001554667,0.00006754881,0.5924607,0.000003874957,0.008161264,0.00007784438],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966899,0.00000585837,0.00001586997,0.001935803,0.0002119452,0.0008561835,0.0001215092,0.00001338136,0.0001496175],"genre_scores_gemma":[0.9967806,0.0008513618,0.0002060725,0.001458933,0.0002225727,0.00001684679,0.00003199634,0.00003017383,0.0004014432],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1612514,"threshold_uncertainty_score":0.5100023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01952108940189791,"score_gpt":0.3045564591308927,"score_spread":0.2850353697289948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}