{"id":"W2143286837","doi":"10.1038/ng.970","title":"Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma","year":2011,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":595,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Western Hospital; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Institute of Diabetes and Digestive and Kidney Diseases; Biocenter, University of Oulu; Helmholtz Zentrum München; Jenny ja Antti Wihurin Rahasto; Medical Research Council; National Institutes of Health; Novo Nordisk Fonden; Instrumentariumin Tiedesäätiö; Universitair Medisch Centrum Groningen; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Karolinska Institutet; Novo Nordisk; Hjärt-Lungfonden; Biomedicum Helsinki-säätiö; Diabetes Fonds; Rijksuniversiteit Groningen; Oulun Yliopisto; Torsten Söderbergs Stiftelse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Science Foundation; School of Medicine, Boston University; European Commission; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; British Heart Foundation; Cancer Research UK; Imperial College Healthcare NHS Trust; Wellcome Trust; Erasmus Medisch Centrum; Directorate for Biological Sciences; Imperial College London; GlaxoSmithKline; National Science Foundation; Knut och Alice Wallenbergs Stiftelse; Nierstichting; Yrjö Jahnssonin Säätiö; AstraZeneca","keywords":"Biology; Candidate gene; Genome-wide association study; Genetics; Gene; Genetic association; KEGG; Single-nucleotide polymorphism; Transcriptome; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001027818,0.00009829421,0.000189265,0.00008400911,0.0000300422,0.000009411418,0.00005906544,0.000147147,0.00008960927],"category_scores_gemma":[0.0001493538,0.0000878811,0.00005557504,0.0001493398,0.00001790983,0.00004240017,0.00002762198,0.0001766498,0.00001228993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001777224,"about_ca_system_score_gemma":0.00008630215,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008499337,"about_ca_topic_score_gemma":0.0003559421,"domain_scores_codex":[0.9991429,0.00004135594,0.000237714,0.0001632366,0.000272497,0.0001423155],"domain_scores_gemma":[0.9993718,0.00009423863,0.0001195897,0.0001711048,0.0001831341,0.00006012456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00003101225,0.0009625113,0.9930378,0.00002792361,0.0001992799,0.00004483164,0.005175862,0.00001237065,0.0001373488,0.00004446187,0.0001935246,0.0001330326],"study_design_scores_gemma":[0.001228214,0.0002062546,0.9753156,0.00002797232,0.0003188514,4.756961e-7,0.0008876545,0.00001871087,0.02177243,0.0000383508,0.0001172379,0.00006824047],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922225,0.006498515,0.000001801087,0.00004391632,0.0000903933,0.0005475984,0.00001879737,0.00001338259,0.0005630211],"genre_scores_gemma":[0.9989547,0.0004357137,0.0002439188,0.0001573106,0.00004272148,0.00002622239,0.00002735391,0.00000979357,0.0001022648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02163508,"threshold_uncertainty_score":0.3583687,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687424622759982,"score_gpt":0.2600229057262388,"score_spread":0.243148659498639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}