{"id":"W2143286837","doi":"10.1038/ng.970","title":"Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma","year":2011,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":595,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Western Hospital; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institute on Alcohol Abuse and Alcoholism; National Institute of Diabetes and Digestive and Kidney Diseases; Biocenter, University of Oulu; Helmholtz Zentrum München; Jenny ja Antti Wihurin Rahasto; Medical Research Council; National Institutes of Health; Novo Nordisk Fonden; Instrumentariumin Tiedesäätiö; Universitair Medisch Centrum Groningen; Vetenskapsrådet; National Institute of Mental Health; Stockholms Läns Landsting; Karolinska Institutet; Novo Nordisk; Hjärt-Lungfonden; Biomedicum Helsinki-säätiö; Diabetes Fonds; Rijksuniversiteit Groningen; Oulun Yliopisto; Torsten Söderbergs Stiftelse; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Science Foundation; School of Medicine, Boston University; European Commission; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; British Heart Foundation; Cancer Research UK; Imperial College Healthcare NHS Trust; Wellcome Trust; Erasmus Medisch Centrum; Directorate for Biological Sciences; Imperial College London; GlaxoSmithKline; National Science Foundation; Knut och Alice Wallenbergs Stiftelse; Nierstichting; Yrjö Jahnssonin Säätiö; AstraZeneca","keywords":"Biology; Candidate gene; Genome-wide association study; Genetics; Gene; Genetic association; KEGG; Single-nucleotide polymorphism; Transcriptome; Gene expression; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009922434,0.0007310459,0.0005140356,0.001274008,0.0005930241,0.0008568754,0.000625561,0.001070327,0.002045454],"category_scores_gemma":[0.001953892,0.0005007841,0.001043822,0.001834556,0.0005905832,0.0003099751,0.0004674557,0.001122347,0.0002202688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002551348,"about_ca_system_score_gemma":0.0002947603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003466891,"about_ca_topic_score_gemma":0.003092685,"domain_scores_codex":[0.9990018,0.0004027878,0.00008394277,0.0003013431,0.0001144811,0.00009567841],"domain_scores_gemma":[0.9983281,0.000735844,0.000449919,0.0001778307,0.0001065587,0.0002016849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005205319,0.0002562662,0.9525711,0.0000606931,0.002519188,0.001383838,0.0002810181,0.0002731704,0.03100626,0.0002659101,0.000522809,0.005654382],"study_design_scores_gemma":[0.0000963594,0.0002155387,0.9964525,0.000005421899,0.0005568035,0.0007880102,0.00007419255,0.0004804572,0.0009274285,0.0001617499,0.0002309453,0.00001069108],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977795,0.000522542,0.0007294493,0.0001713147,0.00002254008,0.000006433279,0.0002688753,0.00002591588,0.0004733525],"genre_scores_gemma":[0.9989911,0.0001083591,0.0004000089,0.00004267774,0.00001939471,0.000005134727,0.0001496137,0.000009881486,0.0002738947],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003466891,"threshold_uncertainty_score":0.006893456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01687424622759982,"score_gpt":0.2600229057262388,"score_spread":0.243148659498639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}