{"id":"W2143299403","doi":"10.1111/j.1365-2958.2006.05459.x","title":"The major surface‐metalloprotease of the parasitic protozoan, <i>Leishmania</i>, protects against antimicrobial peptide‐induced apoptotic killing","year":2006,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, Irvine; National Institute of Allergy and Infectious Diseases; Ohio State University","keywords":"Biology; Magainin; Antimicrobial peptides; Leishmania; Virulence factor; Innate immune system; Leishmania major; Microbiology; Metalloproteinase; Virulence; Cytolysin; Cell biology; Immune system; Antimicrobial; Matrix metalloproteinase; Parasite hosting; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007297716,0.0004096456,0.0006695124,0.00009252541,0.0005326915,0.00005021919,0.0005967254,0.0002333565,0.00001235722],"category_scores_gemma":[0.0005446632,0.0002429258,0.0004234255,0.0004819749,0.0008190573,0.0000472078,0.0002928915,0.000681927,0.00005031108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001422923,"about_ca_system_score_gemma":0.0002798609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000237301,"about_ca_topic_score_gemma":0.0001008942,"domain_scores_codex":[0.996855,0.0005999925,0.0007249106,0.0006127127,0.0002630974,0.0009443358],"domain_scores_gemma":[0.9979403,0.0001845523,0.0003379383,0.001018536,0.0004256647,0.0000929991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001821605,0.0002314181,0.001668304,0.0001928149,0.0002623712,0.00009483433,0.0000489207,0.00006424369,0.9957998,0.0001949629,0.001133207,0.0001269063],"study_design_scores_gemma":[0.001701088,0.0002887365,0.002725772,0.0002165283,0.0001129676,0.0002417335,0.00005132173,0.00004441551,0.990597,0.00008750901,0.003672273,0.0002607277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875349,0.0006386389,0.0001276612,0.004238856,0.0001930897,0.005986673,0.00002377728,0.00006782093,0.001188615],"genre_scores_gemma":[0.9976633,0.00002898237,0.0005482734,0.0007131499,0.00009851112,0.0002548766,0.00003366972,0.00007169132,0.0005875779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0101284,"threshold_uncertainty_score":0.9906225,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137051934814265,"score_gpt":0.2515165727528367,"score_spread":0.2401460534046941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}