{"id":"W2143299403","doi":"10.1111/j.1365-2958.2006.05459.x","title":"The major surface‐metalloprotease of the parasitic protozoan, <i>Leishmania</i>, protects against antimicrobial peptide‐induced apoptotic killing","year":2006,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"University of California, Irvine; National Institute of Allergy and Infectious Diseases; Ohio State University","keywords":"Biology; Magainin; Antimicrobial peptides; Leishmania; Virulence factor; Innate immune system; Leishmania major; Microbiology; Metalloproteinase; Virulence; Cytolysin; Cell biology; Immune system; Antimicrobial; Matrix metalloproteinase; Parasite hosting; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007750144,0.0002111162,0.0001006842,0.0000925581,0.00006295436,0.0001362709,0.00007992252,0.0001350102,0.0009638714],"category_scores_gemma":[0.0001086585,0.00004647794,0.00007779696,0.00004252502,0.0001144176,0.00009250965,0.00007319179,0.0001917417,0.0002965081],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001127921,"about_ca_system_score_gemma":0.00009235567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002073229,"about_ca_topic_score_gemma":0.0001824508,"domain_scores_codex":[0.999956,0.00001120437,0.000002296209,0.000008212615,0.00001023949,0.00001205151],"domain_scores_gemma":[0.9999645,0.000007055997,0.00001048575,0.000002606398,0.000005879313,0.000009524611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009473423,0.00000884045,0.0001462382,0.00002518857,0.000001982501,0.00002010945,0.000003529976,0.000014304,0.9983979,0.00003097798,0.00002459818,0.001231609],"study_design_scores_gemma":[0.00001755264,0.0006720932,0.007916256,0.000007205493,0.00001073028,0.0007046913,0.00002012079,0.0002815645,0.9874932,0.00005996408,0.002814782,0.00000193021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948502,0.002227019,0.001231802,0.00008871894,0.0000131933,0.00001650278,0.0001420549,0.00004640127,0.001384075],"genre_scores_gemma":[0.9967971,0.0008562149,0.0008148428,0.00002391382,0.000006027143,0.000007848091,0.0002020017,0.000005903481,0.001286105],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009638714,"threshold_uncertainty_score":0.003224432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01137051934814265,"score_gpt":0.2515165727528367,"score_spread":0.2401460534046941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}