{"id":"W2143305213","doi":"10.1124/dmd.112.049858","title":"Transport of A1 Adenosine Receptor Agonist Tecadenoson by Human and Mouse Nucleoside Transporters: Evidence for Blood-Brain Barrier Transport by Murine Equilibrative Nucleoside Transporter 1 mENT1","year":2013,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Health Economics; University of Alberta","funders":"Canadian Institutes of Health Research; University of Illinois at Chicago","keywords":"Nucleoside; Adenosine; Nucleoside transporter; Blood–brain barrier; Agonist; Adenosine receptor; Transporter; Biology; Pharmacology; Biochemistry; In vivo; Receptor; Endocrinology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003218751,0.0002722403,0.0002397076,0.0002574054,0.0001800139,0.0005973115,0.0002952066,0.0004025075,0.001054351],"category_scores_gemma":[0.000296997,0.000263864,0.0002629679,0.000132049,0.0002699592,0.0006148328,0.0001414192,0.0004150369,0.0003469017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005015896,"about_ca_system_score_gemma":0.000252352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176128,"about_ca_topic_score_gemma":0.001020513,"domain_scores_codex":[0.9997774,0.00006284144,0.00001811429,0.00005852564,0.00003230521,0.00005082308],"domain_scores_gemma":[0.9998699,0.00003669171,0.00004496428,0.00001940189,0.0000113704,0.00001770178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009258387,0.00002982317,0.0004040842,0.00002910408,0.00001414277,0.00007290707,0.00005891225,0.0001299005,0.9950099,0.001253141,0.00005695987,0.002015326],"study_design_scores_gemma":[0.00003905949,0.0004213594,0.002336999,0.000006862038,0.00003075771,0.0004909941,0.00004794678,0.002513192,0.9915808,0.0001858958,0.00233673,0.000009396529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931731,0.00179918,0.003306695,0.0001149074,0.00001424641,0.00001503403,0.0002381267,0.00003689569,0.001301745],"genre_scores_gemma":[0.9949876,0.0007721848,0.002059301,0.0000376183,0.000006263203,0.00001986683,0.0003509558,0.00003321634,0.00173292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001176128,"threshold_uncertainty_score":0.003639281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008860484400436054,"score_gpt":0.2444397338983343,"score_spread":0.2355792494978983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}