{"id":"W2143321682","doi":"10.1002/anie.200352633","title":"The Tertiary Sulfonamide as a Latent Directed‐Metalation Group: Ni<sup>0</sup>‐Catalyzed Reductive Cleavage and Cross‐Coupling Reactions of Aryl Sulfonamides with Grignard Reagents","year":2004,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Catalytic Cross-Coupling Reactions","field":"Chemistry","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Aryl; Reagent; Metalation; Chemistry; Sulfonamide; Alkyl; Catalysis; Medicinal chemistry; Hydride; Cleavage (geology); Combinatorial chemistry; Grignard reagent; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001786034,0.0004232821,0.0001678192,0.0001097033,0.0001301519,0.0002021984,0.0003349181,0.0001816883,0.00261886],"category_scores_gemma":[0.00009998264,0.0001338133,0.0001456959,0.00009835305,0.0002364537,0.0002417232,0.0002019091,0.0003749689,0.001181184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003924587,"about_ca_system_score_gemma":0.0004440149,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007170953,"about_ca_topic_score_gemma":0.001131948,"domain_scores_codex":[0.9999171,0.00001139729,0.000005998168,0.00001928632,0.0000231208,0.00002312009],"domain_scores_gemma":[0.9999415,0.00000498614,0.00001127018,0.00001393683,0.00001193991,0.00001635426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005746778,0.00001198538,0.00008851958,0.00004581714,0.000003491484,0.000050803,0.00002125556,0.00005624066,0.996244,0.0006777145,0.0001249965,0.002617752],"study_design_scores_gemma":[0.000004097085,0.00006318753,0.0001834423,8.870857e-7,0.000003341473,0.00006157369,0.000002709098,0.0000791925,0.9976011,0.00002409998,0.001975172,0.000001269364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9380096,0.0017609,0.03590129,0.0002757807,0.0001210588,0.0001805166,0.0007374941,0.001214587,0.0217989],"genre_scores_gemma":[0.9787457,0.0006266944,0.009347556,0.00004528253,0.00001071878,0.00004249865,0.0004547949,0.00004401004,0.01068267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00261886,"threshold_uncertainty_score":0.008760929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01056581600361142,"score_gpt":0.2590871927380304,"score_spread":0.248521376734419,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}