{"id":"W2143327184","doi":"10.1161/circheartfailure.108.765750","title":"Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy","year":2009,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Diabetic cardiomyopathy; Extracellular matrix; Cardiology; Cardiomyopathy; Internal medicine; Cardiac function curve; Extracellular; Protein kinase C; Function (biology); Kinase; Cell biology; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000496191,0.0001806727,0.0004356291,0.0002837918,0.00007621323,0.00002580062,0.00001953039,0.0001809042,0.00002670246],"category_scores_gemma":[0.000119518,0.0001774516,0.000229482,0.0004563853,0.0000648105,0.0002723337,0.00001081107,0.0002119016,0.000005899107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009197988,"about_ca_system_score_gemma":0.00005054507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006569128,"about_ca_topic_score_gemma":0.000003383995,"domain_scores_codex":[0.9983953,0.0001848978,0.0004030437,0.0004208366,0.0003994984,0.0001964497],"domain_scores_gemma":[0.9993063,0.00001341962,0.0001042365,0.0003177773,0.0001487191,0.000109554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001278843,0.0001317163,0.08814605,0.0001711915,0.00005041529,0.000002677086,0.0001588003,0.0003108178,0.9067048,0.00007297578,0.0008461777,0.003276478],"study_design_scores_gemma":[0.001452105,0.0003078313,0.811226,0.0003435307,0.0002132057,0.00003092806,0.0004385507,0.0001499357,0.1746624,0.0002826545,0.01061382,0.0002791131],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909763,0.005582642,0.0002109682,0.001600313,0.0001875647,0.001317664,0.00001009965,0.00007812633,0.000036342],"genre_scores_gemma":[0.9989604,0.00004686113,0.0002373915,0.00001385368,0.0001966444,0.00004674265,0.0001663747,0.00001910336,0.0003126776],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7320425,"threshold_uncertainty_score":0.7236268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008406500584161657,"score_gpt":0.2272277887134543,"score_spread":0.2188212881292926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}