{"id":"W2143327184","doi":"10.1161/circheartfailure.108.765750","title":"Inhibition of Protein Kinase C–β by Ruboxistaurin Preserves Cardiac Function and Reduces Extracellular Matrix Production in Diabetic Cardiomyopathy","year":2009,"lang":"en","type":"article","venue":"Circulation Heart Failure","topic":"Cardiovascular Function and Risk Factors","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"","keywords":"Medicine; Diabetic cardiomyopathy; Extracellular matrix; Cardiology; Cardiomyopathy; Internal medicine; Cardiac function curve; Extracellular; Protein kinase C; Function (biology); Kinase; Cell biology; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002479165,0.0005523844,0.0004772088,0.0002491907,0.0001758104,0.0002477492,0.0003459943,0.0002557354,0.001306277],"category_scores_gemma":[0.000139132,0.0001605928,0.0002627829,0.0001686489,0.0002831185,0.0002199838,0.0001479259,0.0007307784,0.0002582589],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002259636,"about_ca_system_score_gemma":0.0003379748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004831211,"about_ca_topic_score_gemma":0.0008282402,"domain_scores_codex":[0.9999108,0.0000107581,0.00001022314,0.0000149653,0.00001562768,0.00003762528],"domain_scores_gemma":[0.9998623,0.00001082121,0.00005549658,0.00001308348,0.00001053956,0.0000477051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004303519,0.0007479133,0.0005299308,0.0001567404,0.00003346292,0.0000637382,0.00002157391,0.0001680513,0.987114,0.00008274068,0.000134632,0.006643742],"study_design_scores_gemma":[0.001437731,0.01236777,0.01294175,0.00004555345,0.0001504963,0.0004636709,0.0001039109,0.001330185,0.9681773,0.00009168029,0.002874842,0.00001509578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957704,0.002302633,0.0007420122,0.0001185512,0.00005644842,0.00003726341,0.000145336,0.00006844683,0.0007588569],"genre_scores_gemma":[0.9938507,0.002644552,0.00166387,0.00009975499,0.00002917446,0.00007104152,0.0002715898,0.00001707854,0.001352237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001306277,"threshold_uncertainty_score":0.004369915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008406500584161657,"score_gpt":0.2272277887134543,"score_spread":0.2188212881292926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}