{"id":"W2143336421","doi":"10.1523/jneurosci.3746-04.2004","title":"Mutation of Glutamate 155 of the GABA<sub>A</sub>Receptor β<sub>2</sub>Subunit Produces a Spontaneously Open Channel: A Trigger for Channel Activation","year":2004,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"Natural Sciences and Engineering Research Council of Canada; U.S. Public Health Service","keywords":"Gating; Chemistry; Allosteric regulation; Protein subunit; AMPA receptor; GABAA receptor; Binding site; Biophysics; Agonist; Ligand (biochemistry); Ligand-gated ion channel; Glutamate receptor; Cysteine; Ion channel; Stereochemistry; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001262218,0.0003980689,0.0002535078,0.0001055313,0.0001059915,0.000236362,0.000209973,0.0002604043,0.0009604837],"category_scores_gemma":[0.0001276601,0.0001648748,0.0003550641,0.0000798465,0.0002911496,0.0001493271,0.0001874679,0.0004685484,0.0004882567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003354358,"about_ca_system_score_gemma":0.0002267204,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005843462,"about_ca_topic_score_gemma":0.000747266,"domain_scores_codex":[0.9998662,0.00002191121,0.00002897011,0.00002640684,0.00003391099,0.00002247283],"domain_scores_gemma":[0.9998509,0.00002737846,0.00005592422,0.00001869443,0.000009269759,0.00003781843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007640514,0.00001284789,0.0001738982,0.00001101316,0.000006085797,0.00009782625,0.000008254337,0.00002398296,0.9992243,0.00006431682,0.00001207062,0.0002889686],"study_design_scores_gemma":[0.00003197348,0.0002592453,0.003539285,0.000005222878,0.0000191227,0.0006666926,0.00002434015,0.0006207718,0.9936719,0.00003553217,0.001120442,0.0000055723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978148,0.0001878694,0.001262489,0.00004478623,0.00002768277,0.00002069517,0.0001472527,0.00003359209,0.0004608309],"genre_scores_gemma":[0.996619,0.000192616,0.001956521,0.00006072434,0.000008215693,0.00002084274,0.0002800724,0.00002669221,0.0008353707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009604837,"threshold_uncertainty_score":0.003213108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007121765796348,"score_gpt":0.273738345942796,"score_spread":0.2536671282848325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}