{"id":"W2143336421","doi":"10.1523/jneurosci.3746-04.2004","title":"Mutation of Glutamate 155 of the GABA<sub>A</sub>Receptor β<sub>2</sub>Subunit Produces a Spontaneously Open Channel: A Trigger for Channel Activation","year":2004,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs","funders":"Natural Sciences and Engineering Research Council of Canada; U.S. Public Health Service","keywords":"Gating; Chemistry; Allosteric regulation; Protein subunit; AMPA receptor; GABAA receptor; Binding site; Biophysics; Agonist; Ligand (biochemistry); Ligand-gated ion channel; Glutamate receptor; Cysteine; Ion channel; Stereochemistry; Receptor; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007893729,0.00019481,0.0003304406,0.000112601,0.00015119,0.0000448557,0.000884169,0.00009782317,7.669377e-7],"category_scores_gemma":[0.001216098,0.0001437715,0.0002051449,0.0004400595,0.0002005748,0.00006286033,0.0002393736,0.0001767683,8.316737e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004750128,"about_ca_system_score_gemma":0.0004443749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005785501,"about_ca_topic_score_gemma":0.00001288138,"domain_scores_codex":[0.9981307,0.0001207159,0.0006737678,0.0003473477,0.0004513635,0.0002760526],"domain_scores_gemma":[0.9976609,0.0000474518,0.00135483,0.000310711,0.0005384855,0.00008767562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003789655,0.0003162223,0.00002852779,0.00003846575,0.00001672626,0.000001451481,0.0002954766,0.001659448,0.9961367,0.000009316898,0.0001645506,0.0009541578],"study_design_scores_gemma":[0.001368455,0.001406197,0.0009318715,0.0001168003,0.00003419372,0.0003162657,0.000138445,0.0001085418,0.9949846,0.0001056683,0.0003470179,0.0001418971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953507,0.00005911628,0.002134415,0.0008855978,0.0006799875,0.0008363813,0.00003419874,0.000004165418,0.00001538951],"genre_scores_gemma":[0.9991248,0.0001882396,0.0001726796,0.0002097338,0.0002263498,0.00002152719,0.000004334817,0.00002715115,0.00002523961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003773996,"threshold_uncertainty_score":0.586283,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02007121765796348,"score_gpt":0.273738345942796,"score_spread":0.2536671282848325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}