{"id":"W2143350483","doi":"10.1038/ng.3176","title":"High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":379,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; Leona M. and Harry B. Helmsley Charitable Trust; Medical Research Council; National Cancer Institute; National Institute of Dental and Craniofacial Research; Seventh Framework Programme; Exzellenzclusters Entzündungsforschung; Agency for Healthcare Research and Quality; Crohn's and Colitis UK; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Institut National Du Cancer; National Health and Medical Research Council; NIHR Cambridge Biomedical Research Centre; Multiple Sclerosis Society; Academy of Medical Sciences; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Wellcome Trust; Frederick National Laboratory for Cancer Research; European Commission; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Ulcerative colitis; Biology; Inflammatory bowel disease; Human leukocyte antigen; Inflammatory Bowel Diseases; Major histocompatibility complex; Immunology; Genetics; Internal medicine; Antigen; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002423627,0.0002043537,0.000212119,0.0006436172,0.0002672666,0.0003299164,0.0002870689,0.0003439341,0.00276826],"category_scores_gemma":[0.0003978446,0.0002069626,0.0002324017,0.0003193439,0.000260273,0.0001275727,0.0004028399,0.0004233443,0.0003128224],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008886644,"about_ca_system_score_gemma":0.0000490187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005446183,"about_ca_topic_score_gemma":0.00075537,"domain_scores_codex":[0.9997913,0.00005929088,0.00001919359,0.00004259137,0.00004468026,0.00004297432],"domain_scores_gemma":[0.9997037,0.00008993895,0.00008195168,0.00003176431,0.00001891817,0.00007357459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008884274,0.00005473563,0.02975344,0.00002720501,0.00006217496,0.0008700024,0.000100903,0.0000671285,0.9638265,0.0004872168,0.0001166419,0.003745694],"study_design_scores_gemma":[0.0001454124,0.0003782069,0.8886552,0.00002233187,0.0001610319,0.01138747,0.0004637836,0.001711287,0.09442025,0.0009463658,0.001685176,0.00002360052],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986916,0.0001635175,0.0005534242,0.00005109122,0.000006427999,0.000001448135,0.00004394948,0.000006399795,0.000481988],"genre_scores_gemma":[0.9992869,0.0000381031,0.0003907386,0.00002193438,0.000005294127,0.000001662148,0.00003777696,0.000007655979,0.0002100509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00276826,"threshold_uncertainty_score":0.009260714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006087171765397476,"score_gpt":0.2359742929411187,"score_spread":0.2298871211757213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}