{"id":"W2143350483","doi":"10.1038/ng.3176","title":"High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis","year":2015,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":379,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Center for Advancing Translational Sciences; Leona M. and Harry B. Helmsley Charitable Trust; Medical Research Council; National Cancer Institute; National Institute of Dental and Craniofacial Research; Seventh Framework Programme; Exzellenzclusters Entzündungsforschung; Agency for Healthcare Research and Quality; Crohn's and Colitis UK; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Institut National Du Cancer; National Health and Medical Research Council; NIHR Cambridge Biomedical Research Centre; Multiple Sclerosis Society; Academy of Medical Sciences; National Institute of Neurological Disorders and Stroke; University of Pittsburgh; Wellcome Trust; Frederick National Laboratory for Cancer Research; European Commission; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Ulcerative colitis; Biology; Inflammatory bowel disease; Human leukocyte antigen; Inflammatory Bowel Diseases; Major histocompatibility complex; Immunology; Genetics; Internal medicine; Antigen; Disease; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00019551,0.000201495,0.0001992785,0.00008046124,0.00005291704,0.00003751851,0.0002406821,0.0003205237,0.000002370107],"category_scores_gemma":[0.0002868508,0.0001824322,0.00008368671,0.00008771727,0.0001482672,0.00001095155,0.0002541872,0.0002029335,8.857211e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004786273,"about_ca_system_score_gemma":0.0001850349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001519768,"about_ca_topic_score_gemma":0.001383533,"domain_scores_codex":[0.998731,0.000120122,0.0003209863,0.0003622428,0.0001953268,0.0002702784],"domain_scores_gemma":[0.9991463,0.00002282482,0.0001433129,0.0003921057,0.0001765901,0.0001188088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001965402,0.0001901052,0.9118388,0.0004362719,0.000102594,0.0001263685,0.001614499,0.0008909653,0.08014533,0.0001672046,0.001682296,0.0008401739],"study_design_scores_gemma":[0.001755607,0.00005698731,0.970306,0.00006856589,0.0000244094,0.000005901684,0.0005771117,0.0002536202,0.02509592,0.0008672907,0.0007702271,0.0002183963],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963824,0.002124419,0.00003175431,0.00004982993,0.0002923876,0.0007204619,0.0003505222,0.000008364137,0.00003992834],"genre_scores_gemma":[0.9989225,0.00008918095,0.0003722614,0.0001964536,0.0001425589,0.00007104719,0.00009321265,0.00002674233,0.00008600622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05846716,"threshold_uncertainty_score":0.7439368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006087171765397476,"score_gpt":0.2359742929411187,"score_spread":0.2298871211757213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}