{"id":"W2143367061","doi":"10.1074/jbc.m112.346437","title":"Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"PINK1; Parkin; MPTP; Pars compacta; Substantia nigra; Dopaminergic; Biology; Dopamine; Parkinson's disease; Gene knockdown; Cell biology; Striatum; Ectopic expression; Neuroscience; Internal medicine; Genetics; Medicine; Gene; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001564586,0.0006798378,0.0002962287,0.0003735653,0.0001958976,0.0003295317,0.0003375122,0.0003691711,0.001693113],"category_scores_gemma":[0.0001118096,0.0002862178,0.0002844569,0.00020016,0.0004278914,0.0003060014,0.0002897152,0.000950093,0.0004347428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004667066,"about_ca_system_score_gemma":0.0003251666,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000890763,"about_ca_topic_score_gemma":0.001728538,"domain_scores_codex":[0.9997738,0.00002296593,0.00002939405,0.00006662431,0.00005831233,0.00004887745],"domain_scores_gemma":[0.9998176,0.00002130789,0.00006885091,0.00001866506,0.000009187495,0.00006447781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003433196,0.00001316342,0.00007539599,0.00002363678,0.000004113124,0.00003355727,0.0000141145,0.00004430358,0.9993942,0.00006788523,0.00001790666,0.0002772723],"study_design_scores_gemma":[0.00001059247,0.0001856992,0.001795833,0.00000474538,0.00001597272,0.0001729172,0.00001843368,0.0007577768,0.9958981,0.00004711113,0.001089616,0.00000317407],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934667,0.0009189671,0.003615431,0.000149706,0.00003918195,0.00003057179,0.0005735017,0.0001568338,0.001049164],"genre_scores_gemma":[0.9898891,0.001303444,0.003125435,0.00005348643,0.00001001659,0.00006530061,0.0007569289,0.00004424794,0.004752153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001693113,"threshold_uncertainty_score":0.005663991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02897082399246661,"score_gpt":0.2774254384436153,"score_spread":0.2484546144511487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}