{"id":"W2143373491","doi":"10.1146/annurev.biochem.78.070907.103305","title":"Large-Scale Structural Biology of the Human Proteome","year":2009,"lang":"en","type":"review","venue":"Annual Review of Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; Wellcome Trust","keywords":"Human proteome project; Human proteins; Biology; Computational biology; Proteome; Function (biology); Protein structure; Epigenetics; Proteomics; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005868392,0.0007694894,0.0007506579,0.00110576,0.0002615783,0.0008626847,0.0007094429,0.001099288,0.001393896],"category_scores_gemma":[0.0004361734,0.0003362773,0.0003117842,0.0011871,0.00089402,0.001679622,0.0008881146,0.001668194,0.002565088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001081794,"about_ca_system_score_gemma":0.001206498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009981242,"about_ca_topic_score_gemma":0.0009640055,"domain_scores_codex":[0.9998531,0.0000254809,0.00001138653,0.00003201176,0.00006329974,0.00001458533],"domain_scores_gemma":[0.999836,0.00006032062,0.00002177423,0.00001300023,0.00004837159,0.00002053196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006914294,0.00005406016,0.0002558515,0.007381802,0.0000715522,0.0004038477,0.0001052649,0.001115308,0.02654083,0.03052109,0.06364511,0.8698362],"study_design_scores_gemma":[0.00001430765,0.00004177782,0.0008324719,0.000664982,0.00002632244,0.001795907,0.00004918519,0.0002262342,0.005854309,0.0135214,0.9769526,0.00002058677],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002979331,0.9954824,0.000961163,0.0007341444,0.0002659363,0.000006287316,0.00002519495,0.00001792134,0.002209008],"genre_scores_gemma":[0.001888509,0.9958304,0.0005924623,0.0002597631,0.0002920225,0.000008704389,0.0000506704,0.00000290549,0.001074668],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001393896,"threshold_uncertainty_score":0.007848978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01576375942312392,"score_gpt":0.3282690470598221,"score_spread":0.3125052876366982,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}