{"id":"W2143378108","doi":"10.1158/1541-7786.mcr-11-0097","title":"Breast Cancer Cells Proliferation Is Regulated by Tyrosine Phosphatase SHP1 through c-jun N-Terminal Kinase and Cooperative Induction of RFX-1 and AP-4 Transcription Factors","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Health Canada","funders":"Health Canada; University of Calgary","keywords":"Cancer research; Signal transduction; Cell growth; Kinase; Transcription factor; Protein tyrosine phosphatase; Cancer cell; Biology; MAPK/ERK pathway; Cancer; Cell biology; Chemistry; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001142401,0.0004102851,0.0001891584,0.0003133086,0.0002193538,0.0002002197,0.0001509262,0.0001447852,0.001034364],"category_scores_gemma":[0.00007511271,0.0001253624,0.0002363081,0.0001516455,0.0001695379,0.0001461113,0.000220251,0.0004109729,0.0003990949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236506,"about_ca_system_score_gemma":0.0002055885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005703127,"about_ca_topic_score_gemma":0.0008288911,"domain_scores_codex":[0.9998845,0.00001424654,0.000006250183,0.00002203588,0.00004082875,0.00003216381],"domain_scores_gemma":[0.9999353,0.000009415489,0.0000220354,0.00000587593,0.00001367274,0.00001366756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007996918,0.00001917555,0.0005475207,0.00007654254,0.000005361659,0.00007525805,0.00001752219,0.00004357475,0.9961158,0.00005500517,0.00005325795,0.002911088],"study_design_scores_gemma":[0.00001401096,0.0002178487,0.02945671,0.000009401596,0.00002130102,0.0005166158,0.00006384402,0.001081124,0.9640649,0.00008164514,0.004466776,0.00000586844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811606,0.009585767,0.005814974,0.000193668,0.0000420002,0.00004514885,0.0004380395,0.0001752168,0.002544654],"genre_scores_gemma":[0.9888011,0.00399035,0.002662454,0.00005071639,0.00002483503,0.00007861718,0.0006936519,0.00001264998,0.003685599],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001034364,"threshold_uncertainty_score":0.003460348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03946757071506852,"score_gpt":0.3194746461706553,"score_spread":0.2800070754555868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}