{"id":"W2143378108","doi":"10.1158/1541-7786.mcr-11-0097","title":"Breast Cancer Cells Proliferation Is Regulated by Tyrosine Phosphatase SHP1 through c-jun N-Terminal Kinase and Cooperative Induction of RFX-1 and AP-4 Transcription Factors","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Research","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa; Health Canada","funders":"Health Canada; University of Calgary","keywords":"Cancer research; Signal transduction; Cell growth; Kinase; Transcription factor; Protein tyrosine phosphatase; Cancer cell; Biology; MAPK/ERK pathway; Cancer; Cell biology; Chemistry; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002330367,0.0002300224,0.0002138521,0.00007269365,0.0001639974,0.00004632459,0.0001405102,0.0001923948,0.0001140634],"category_scores_gemma":[0.00002062386,0.0002141869,0.00004184093,0.0002634906,0.0004387043,0.00004556921,0.0001015103,0.0001758494,9.050248e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005357245,"about_ca_system_score_gemma":0.0001697295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003811622,"about_ca_topic_score_gemma":0.0001157258,"domain_scores_codex":[0.9982587,0.0001901474,0.0002574805,0.0005870984,0.0003529419,0.0003536487],"domain_scores_gemma":[0.9990511,0.00000643491,0.0000921443,0.0002998328,0.0004227207,0.0001277951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007146025,0.0001161222,0.00097213,0.0001085252,0.00007857882,0.00001000095,0.0006085088,0.00000735905,0.9916717,0.000165559,0.002286898,0.003259971],"study_design_scores_gemma":[0.0008921644,0.0004216838,0.002221854,0.00008489341,0.00003869493,0.00001917247,0.0001059292,0.00004575898,0.9951946,0.00006561097,0.000691027,0.0002186643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609417,0.03554517,0.0006393387,0.0002441199,0.00006969906,0.0007530469,0.001778942,0.0000100559,0.00001790713],"genre_scores_gemma":[0.9952736,0.003572331,0.000209787,0.0001064509,0.00004994733,0.0002128579,0.000430281,0.00003776627,0.0001069647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03433189,"threshold_uncertainty_score":0.8734287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03946757071506852,"score_gpt":0.3194746461706553,"score_spread":0.2800070754555868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}