{"id":"W2143379599","doi":"10.1310/fgmf-y0ly-dmx8-371v","title":"Predictors of Long-Term Immunological Outcome in Rebounding Patients on Protease Inhibitor-Based HAART After Initial Successful Virologic Suppression: Implications for Timing to Switch","year":2003,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"McMaster University; Bayer Corporation","keywords":"Medicine; Viremia; Viral load; Internal medicine; Protease inhibitor (pharmacology); Univariate analysis; Gastroenterology; Reverse-transcriptase inhibitor; Immunology; Retrospective cohort study; Multivariate analysis; Area under the curve; Human immunodeficiency virus (HIV); Antiretroviral therapy","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006797098,0.000291504,0.000282949,0.000378019,0.0002319475,0.0004885424,0.0002620641,0.0004885386,0.0011643],"category_scores_gemma":[0.002982005,0.0001381989,0.0003148417,0.0003727244,0.000246613,0.0003421606,0.000214965,0.0005813088,0.0002399507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001737105,"about_ca_system_score_gemma":0.0002449445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009236733,"about_ca_topic_score_gemma":0.0008037002,"domain_scores_codex":[0.9997556,0.00007776344,0.00003001592,0.00004323039,0.00003677544,0.00005660762],"domain_scores_gemma":[0.9975744,0.000721404,0.001006512,0.00007450666,0.0001399951,0.0004832461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002506197,0.0000248026,0.9986569,0.000003211836,0.00001288117,0.00006347702,0.00001316953,0.00004763091,0.0001349333,0.00000344403,0.00002269265,0.0007661178],"study_design_scores_gemma":[0.00001426989,0.0002908756,0.9985871,0.000006415256,0.00002181511,0.0004262552,0.00006995862,0.0004115326,0.00007825287,0.00001237649,0.00007865997,0.000002531809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995547,0.000231445,0.00003777663,0.00003210553,0.000003406898,0.000002841172,0.00003878295,0.00000153551,0.00009725746],"genre_scores_gemma":[0.9997728,0.00004545082,0.00003240825,0.000008754364,0.00001061199,0.00000236024,0.00008482856,7.976958e-7,0.00004198373],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0011643,"threshold_uncertainty_score":0.003894925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.220466695654694,"score_gpt":0.4709658042581454,"score_spread":0.2504991086034514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}