{"id":"W2143427195","doi":"10.1007/s00395-012-0326-9","title":"Interferon regulatory factor 3 is a negative regulator of pathological cardiac hypertrophy","year":2013,"lang":"en","type":"article","venue":"Basic Research in Cardiology","topic":"Cardiac Fibrosis and Remodeling","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Heart and Stroke Foundation; University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"IRF3; Muscle hypertrophy; Pressure overload; Interferon regulatory factors; Transcription factor; Heart failure; Internal medicine; Biology; Endocrinology; Pathological; Medicine; Cancer research; Cardiac hypertrophy; Innate immune system; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001244001,0.0002028798,0.001183813,0.0004515841,0.00006112215,0.00001588179,0.0001813801,0.000406228,0.0001644163],"category_scores_gemma":[0.0004072076,0.0001471325,0.0005193013,0.0004530626,0.000761118,0.00008951708,0.0002713203,0.0008304277,0.0001067709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002411875,"about_ca_system_score_gemma":0.0002089593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002541944,"about_ca_topic_score_gemma":7.97673e-7,"domain_scores_codex":[0.9965936,0.0009514153,0.000527174,0.0005992638,0.0006238101,0.0007047204],"domain_scores_gemma":[0.997805,0.0005412721,0.00006822177,0.000770983,0.0005875689,0.0002269538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001237178,0.0001890861,0.2893006,0.0003768769,0.0005051149,0.0001416801,0.001500177,0.00007807119,0.6286222,0.0007355205,0.02482964,0.05248388],"study_design_scores_gemma":[0.001187115,0.001250181,0.9805856,0.0002217186,0.00002831993,0.00006621372,0.0007327636,0.0002876235,0.0117947,0.001400877,0.002248749,0.000196165],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915746,0.001090409,0.0000328005,0.001104999,0.0002953075,0.0009914114,0.00004254864,0.00002744088,0.004840497],"genre_scores_gemma":[0.9980731,0.0003489656,0.0005404588,0.0001104218,0.0004351995,0.0001413974,0.00001152829,0.0000312626,0.0003076369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.691285,"threshold_uncertainty_score":0.5999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09862822021555716,"score_gpt":0.3646902091369826,"score_spread":0.2660619889214254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}