{"id":"W2143505338","doi":"10.4049/jimmunol.0902660","title":"The Alarmin Cytokine, High Mobility Group Box 1, Is Produced by Viable Cardiomyocytes and Mediates the Lipopolysaccharide-Induced Myocardial Dysfunction via a TLR4/Phosphatidylinositol 3-Kinase γ Pathway","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"HMGB1; Contractility; Myocyte; TLR4; PI3K/AKT/mTOR pathway; Lipopolysaccharide; Internal medicine; In vivo; Endocrinology; Biology; Secretion; Medicine; Pharmacology; Inflammation; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002139687,0.0005034292,0.000283718,0.0001844893,0.0001307629,0.0001978968,0.0001146649,0.0003293238,0.0009442673],"category_scores_gemma":[0.00009535652,0.0001322588,0.0002219924,0.0000786548,0.0002447848,0.0002322548,0.0002635675,0.0005161375,0.0001858212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001240027,"about_ca_system_score_gemma":0.0001068934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007731425,"about_ca_topic_score_gemma":0.00009046041,"domain_scores_codex":[0.9998686,0.00002515341,0.00001276358,0.00002652229,0.00003525293,0.0000316588],"domain_scores_gemma":[0.999885,0.00001019445,0.00005000347,0.000007269701,0.000008383892,0.00003917476],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001888767,0.00001478528,0.0003338499,0.00003471766,0.000005175747,0.00008999625,0.000009023986,0.00001624096,0.998442,0.00003906197,0.00001460631,0.0008117832],"study_design_scores_gemma":[0.00007086264,0.001736798,0.03030683,0.00002211115,0.00005670833,0.0009283073,0.00009291882,0.0007851514,0.9642956,0.0002040794,0.001490742,0.00000994533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919662,0.003402667,0.003649756,0.0001537196,0.00005127998,0.00002507626,0.0001799562,0.00004692952,0.0005243248],"genre_scores_gemma":[0.9945115,0.002060304,0.001907478,0.00008588845,0.00004005284,0.00004192737,0.0002615385,0.000007156269,0.001084136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009442673,"threshold_uncertainty_score":0.003158867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006360179000942143,"score_gpt":0.2401227781283001,"score_spread":0.2337625991273579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}