{"id":"W2143505338","doi":"10.4049/jimmunol.0902660","title":"The Alarmin Cytokine, High Mobility Group Box 1, Is Produced by Viable Cardiomyocytes and Mediates the Lipopolysaccharide-Induced Myocardial Dysfunction via a TLR4/Phosphatidylinositol 3-Kinase γ Pathway","year":2009,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Lawson Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"HMGB1; Contractility; Myocyte; TLR4; PI3K/AKT/mTOR pathway; Lipopolysaccharide; Internal medicine; In vivo; Endocrinology; Biology; Secretion; Medicine; Pharmacology; Inflammation; Cell biology; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001905024,0.000216258,0.0002795144,0.00004342338,0.0005432557,0.00004780552,0.000589475,0.0001582286,0.000009439568],"category_scores_gemma":[0.0006752028,0.0001115164,0.0001119744,0.0001652246,0.0003301477,0.0000288358,0.0001474298,0.0005022169,0.00000414297],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004629802,"about_ca_system_score_gemma":0.0001313488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008243833,"about_ca_topic_score_gemma":0.000006098292,"domain_scores_codex":[0.9979107,0.0006457871,0.0004798481,0.0002787579,0.0002987726,0.0003861189],"domain_scores_gemma":[0.9981382,0.0002237689,0.0004007678,0.0007569781,0.0004167855,0.00006351447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009004713,0.00006926596,0.0001398863,0.000004089749,0.0002368209,0.000002132268,0.0001570206,0.00002508166,0.9692112,0.00006334271,0.001434919,0.02775577],"study_design_scores_gemma":[0.0007474045,0.001283995,0.003179153,0.000006290085,0.00006333416,0.0001925351,0.0002474286,0.00001664757,0.9737653,0.0007885312,0.01957701,0.0001323801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9717945,0.016191,0.001193806,0.009772867,0.0005402996,0.0004571093,0.00001871529,0.000009677082,0.00002198732],"genre_scores_gemma":[0.9932612,0.005481311,0.00009633131,0.0004370277,0.0005453103,0.00001755222,0.00001455243,0.00001831038,0.0001283956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02762339,"threshold_uncertainty_score":0.4547506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006360179000942143,"score_gpt":0.2401227781283001,"score_spread":0.2337625991273579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}