{"id":"W2143554177","doi":"10.1371/journal.pone.0040913","title":"Cleavage of Phage DNA by the Streptococcus thermophilus CRISPR3-Cas System","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Streptococcus thermophilus; Trans-activating crRNA; Plasmid; Biology; Palindrome; Genome; DNA; Genetics; Bacteriophage; Rolling circle replication; Nucleic acid; Microbiology; Gene; Bacteria; DNA replication; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002656415,0.0004781355,0.0004808531,0.0002576136,0.0001877165,0.0004032458,0.0002818709,0.0003875262,0.001093057],"category_scores_gemma":[0.0003919964,0.0002347257,0.0004586417,0.0002115636,0.000239495,0.0001871341,0.0003625396,0.0006052363,0.0006378693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003992521,"about_ca_system_score_gemma":0.0003071182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008866556,"about_ca_topic_score_gemma":0.001080299,"domain_scores_codex":[0.9996032,0.00007609352,0.00005275652,0.00007914662,0.0001316718,0.0000571499],"domain_scores_gemma":[0.9997336,0.00006547257,0.00006926668,0.00005199792,0.00004052979,0.00003918314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004887061,0.000008678936,0.0001882685,0.00003685902,0.000006108567,0.00003625028,0.00001115378,0.0001108266,0.9979955,0.00008326468,0.00002994525,0.001444297],"study_design_scores_gemma":[0.000003937239,0.00004645791,0.001358202,0.000004061062,0.000007038956,0.0001823655,0.000009019282,0.001439887,0.9958633,0.00004178524,0.001038276,0.000005693101],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613848,0.001355046,0.03319207,0.00009864157,0.00005128641,0.00007845103,0.0006313837,0.0005417991,0.002666575],"genre_scores_gemma":[0.9764519,0.0004104958,0.01880303,0.00004897897,0.000006248108,0.00004847127,0.0008124931,0.00006968796,0.003348715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093057,"threshold_uncertainty_score":0.003656626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669406181959242,"score_gpt":0.2549414086113949,"score_spread":0.2382473467918025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}