{"id":"W2143554177","doi":"10.1371/journal.pone.0040913","title":"Cleavage of Phage DNA by the Streptococcus thermophilus CRISPR3-Cas System","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"CRISPR; Streptococcus thermophilus; Trans-activating crRNA; Plasmid; Biology; Palindrome; Genome; DNA; Genetics; Bacteriophage; Rolling circle replication; Nucleic acid; Microbiology; Gene; Bacteria; DNA replication; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522437,0.0001166674,0.0001399536,0.00001382357,0.00004221388,0.000007837212,0.0001826795,0.00008276592,0.00001563052],"category_scores_gemma":[0.00002625029,0.00008840273,0.00005960527,0.00004996778,0.00003932335,0.000002494881,0.00007398435,0.00006826773,0.00001704733],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009734794,"about_ca_system_score_gemma":0.000009130197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008588082,"about_ca_topic_score_gemma":0.000002485844,"domain_scores_codex":[0.999274,0.00003343125,0.000166212,0.0001404114,0.0001493442,0.0002366424],"domain_scores_gemma":[0.9994324,0.0000131535,0.00005589516,0.0003977238,0.00003262898,0.0000681438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001279681,0.00023284,0.001623045,0.0001080442,0.0001468364,4.902666e-7,0.0001116779,0.000004571512,0.9955523,0.00004421366,0.001753801,0.000409358],"study_design_scores_gemma":[0.000202558,0.00008224855,0.002293953,0.00003419654,0.00007292564,0.000003489466,0.0001946101,0.0000464086,0.9958106,0.000001628086,0.001149742,0.0001076378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990936,0.004260902,0.0009828785,0.00005636211,0.00007600129,0.0002581963,0.00005184827,0.00002013091,0.00335771],"genre_scores_gemma":[0.9990144,0.00006652017,0.0001468768,0.00003844007,0.0002837776,0.00003269648,0.00002804608,0.00002468262,0.0003646027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008078387,"threshold_uncertainty_score":0.3604959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01669406181959242,"score_gpt":0.2549414086113949,"score_spread":0.2382473467918025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}