{"id":"W2143579583","doi":"10.2174/157340205774574559","title":"Cardiotonic Steroids: Novel Mechanisms of Na+ i-Mediated and - Independent Signaling Involved in the Regulation of Gene Expression, Proliferation and Cell Death","year":2005,"lang":"en","type":"article","venue":"Current Hypertension Reviews","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Programmed cell death; Vascular smooth muscle; Apoptosis; Cell biology; Cell growth; Medicine; Kidney; Cell; Endocrinology; Endothelial stem cell; Signal transduction; Internal medicine; Cancer research; Biology; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004744351,0.00011388,0.0002377367,0.0000483061,0.00003340234,0.000006249583,0.00005845141,0.0000903671,0.000002430836],"category_scores_gemma":[0.0000240248,0.00007671956,0.00005207943,0.00006603157,0.0000243554,0.00001052368,0.00001860078,0.0000612635,3.212049e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005438626,"about_ca_system_score_gemma":0.00001922082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002365927,"about_ca_topic_score_gemma":0.000005939421,"domain_scores_codex":[0.9990465,0.00008877403,0.000421345,0.0002080784,0.000149084,0.00008619982],"domain_scores_gemma":[0.9994903,0.00001032673,0.0002090457,0.0001708773,0.00009146291,0.00002802504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002761455,0.0000729444,0.001451351,0.0001295359,0.000003335634,9.406657e-8,0.0001455759,0.00008504812,0.9951889,0.00002105287,0.00002448566,0.002850064],"study_design_scores_gemma":[0.0008944413,0.000100561,0.01278989,0.0002423295,0.0000426073,0.000006129816,0.00009278605,0.001800908,0.9821141,0.00003836148,0.001761277,0.0001166062],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9674723,0.02210692,0.009754821,0.00003593614,0.00005749171,0.0005595007,0.000006437544,0.000002315163,0.000004271357],"genre_scores_gemma":[0.9930443,0.005431095,0.00117127,0.00004953619,0.00005305321,0.00002589847,0.0002127723,0.000007539011,0.000004562464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02557197,"threshold_uncertainty_score":0.3128533,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356135680548172,"score_gpt":0.2498150055123935,"score_spread":0.2142014374575763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}