{"id":"W2143579583","doi":"10.2174/157340205774574559","title":"Cardiotonic Steroids: Novel Mechanisms of Na+ i-Mediated and - Independent Signaling Involved in the Regulation of Gene Expression, Proliferation and Cell Death","year":2005,"lang":"en","type":"article","venue":"Current Hypertension Reviews","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôtel-Dieu de Montréal","funders":"Canadian Institutes of Health Research","keywords":"Programmed cell death; Vascular smooth muscle; Apoptosis; Cell biology; Cell growth; Medicine; Kidney; Cell; Endocrinology; Endothelial stem cell; Signal transduction; Internal medicine; Cancer research; Biology; Biochemistry; Smooth muscle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002259728,0.0007346618,0.0007681205,0.0009922354,0.0002421116,0.001074863,0.00052652,0.0007184161,0.001409209],"category_scores_gemma":[0.0001902152,0.0002048068,0.0003806959,0.0007927941,0.0004230792,0.0009590468,0.0004264696,0.001082404,0.0007706048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004382287,"about_ca_system_score_gemma":0.0004774787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004010444,"about_ca_topic_score_gemma":0.0006762729,"domain_scores_codex":[0.9998388,0.00002219351,0.00002898408,0.00003791443,0.00005128208,0.00002083663],"domain_scores_gemma":[0.9999186,0.00002144321,0.00002193837,0.000003152996,0.00002368491,0.00001112769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004083359,0.0001503661,0.0007207625,0.03307747,0.0002569944,0.00168917,0.0003628522,0.0009380656,0.1074116,0.01624748,0.01620979,0.8225271],"study_design_scores_gemma":[0.00005449649,0.0003786907,0.002461633,0.0009591112,0.0002106899,0.003780948,0.0001395467,0.0003092175,0.02406705,0.003974886,0.963613,0.00005078454],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001022005,0.9965327,0.0007069584,0.0002720343,0.0002307433,0.000008462087,0.00004774689,0.0000185862,0.001160882],"genre_scores_gemma":[0.008581591,0.988516,0.0004701974,0.0002692539,0.0006187558,0.00001898412,0.0001000763,0.000003665716,0.001421527],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001409209,"threshold_uncertainty_score":0.004714251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0356135680548172,"score_gpt":0.2498150055123935,"score_spread":0.2142014374575763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}