{"id":"W2143585699","doi":"10.2337/db13-0425","title":"Epidermal Growth Factor Receptor Signaling Promotes Pancreatic β-Cell Proliferation in Response to Nutrient Excess in Rats Through mTOR and FOXM1","year":2013,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"PI3K/AKT/mTOR pathway; Epidermal growth factor; Cell growth; Ribosomal protein s6; Growth factor; Endocrinology; Biology; Epidermal growth factor receptor; Insulin-like growth factor; Internal medicine; Cell biology; Receptor; Signal transduction; Cancer research; Medicine; Biochemistry; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004127422,0.0002376882,0.000512619,0.0002861067,0.0000536258,0.00007346021,0.00006295621,0.000120048,0.0002975455],"category_scores_gemma":[0.001598726,0.0001999861,0.00004486562,0.000431708,0.00004891235,0.0003573964,0.0000390396,0.0001736118,0.000119365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001115738,"about_ca_system_score_gemma":0.0001015007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001123601,"about_ca_topic_score_gemma":0.000003280414,"domain_scores_codex":[0.9981664,0.0002672667,0.0004680388,0.0004041203,0.0002361762,0.0004579913],"domain_scores_gemma":[0.99866,0.000731767,0.0000854067,0.000195211,0.0001235649,0.0002040254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002363537,0.0002166645,0.4322278,0.0002218368,0.00001248775,0.000002919676,0.001655072,0.000002655166,0.5647417,0.00002870596,0.0003029872,0.0003508747],"study_design_scores_gemma":[0.002493615,0.0006141039,0.2044714,0.0005558328,0.0000273632,8.615248e-7,0.0004588075,0.0006881547,0.7896451,0.0005920216,0.0001759949,0.000276735],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995113,0.0004829718,0.00003894043,0.002241613,0.0001063816,0.001715374,0.00001030449,0.00006299093,0.0002284481],"genre_scores_gemma":[0.9956949,0.00002296175,0.002141015,0.001085539,0.00009789908,0.000568703,0.00002702259,0.00002949525,0.000332426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2277564,"threshold_uncertainty_score":0.8155195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01757982909368487,"score_gpt":0.2497048431837173,"score_spread":0.2321250140900325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}