{"id":"W2143604504","doi":"10.1186/1750-1326-5-43","title":"Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease","year":2010,"lang":"en","type":"article","venue":"Molecular Neurodegeneration","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":148,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Krembil Foundation","keywords":"Substantia nigra; Alpha-synuclein; Viral vector; Green fluorescent protein; Neurite; Parkinson's disease; Context (archaeology); Cell biology; Neuroscience; Biology; Dopaminergic; Striatum; Synucleinopathies; Pathology; Medicine; Dopamine; Biochemistry; Gene; Disease; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002574835,0.0002661248,0.0002914374,0.0002202374,0.0002086405,0.00005157769,0.0001289492,0.0000834107,0.000002514894],"category_scores_gemma":[0.00008187193,0.0001570672,0.00005774353,0.0003401331,0.0001317691,0.000119237,0.0000423748,0.0002475091,1.300781e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504232,"about_ca_system_score_gemma":0.0001542798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002696384,"about_ca_topic_score_gemma":0.0001773429,"domain_scores_codex":[0.9981563,0.0002858559,0.0003355166,0.0005632699,0.0004277253,0.0002313068],"domain_scores_gemma":[0.9988994,0.00001472219,0.0002567634,0.0005257873,0.0001955564,0.0001077769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008531445,0.0003033774,0.001700807,0.00005011825,0.00001632039,0.0002663643,0.0005052528,0.01757889,0.9782404,0.0002190503,0.000001818819,0.0002644054],"study_design_scores_gemma":[0.002345226,0.0008800763,0.0235837,0.0001418254,0.0002614414,0.0001779145,0.00003384771,0.03082458,0.9414696,0.00009767936,0.000006948315,0.0001772143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9419853,0.0002258674,0.05531067,0.0005849891,0.000042948,0.001787364,0.0000454829,0.00001594529,0.000001426199],"genre_scores_gemma":[0.9900144,0.00000594324,0.009424665,0.0001602447,0.0000636433,0.0001815321,0.0001044736,0.0000413544,0.00000369829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04802914,"threshold_uncertainty_score":0.6405014,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01062047260594155,"score_gpt":0.2299874444899964,"score_spread":0.2193669718840549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}