{"id":"W2143625465","doi":"10.1038/nature11582","title":"Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease","year":2012,"lang":"en","type":"review","venue":"Nature","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4859,"is_retracted":false,"has_abstract":false,"ca_institutions":"Mount Sinai Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre; Université de Montréal; University of Toronto; Royal Victoria Hospital; Montreal Heart Institute","funders":"National Cancer Institute; Helmholtz Zentrum München; National Health and Medical Research Council; Inflammatory Bowel and Immunobiology Research Institute; National Center for Research Resources; National Institute of Allergy and Infectious Diseases; Versus Arthritis; National Institutes of Health; Svenska Läkaresällskapet; Karolinska Institutet; Crohn's and Colitis UK; Ministero della Salute; Diabetes UK; Fonds Wetenschappelijk Onderzoek; U.S. Public Health Service; National Human Genome Research Institute; Fonds De La Recherche Scientifique - FNRS; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; Cedars-Sinai Medical Center; Deutsche Forschungsgemeinschaft; Universitetssjukhuset Örebro; King's College London; Crohn's and Colitis Foundation of America; National Institute of General Medical Sciences; Crohn's and Colitis Foundation; Münchner Zentrum für Gesundheitswissenschaften; Exzellenzclusters Entzündungsforschung; British Heart Foundation; Wellcome Trust; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Örebro Universitet; National Center for Advancing Translational Sciences; Medical Research Council; Leona M. and Harry B. Helmsley Charitable Trust","keywords":"Inflammatory bowel disease; Host (biology); Disease; Inflammatory Bowel Diseases; Genetic architecture; Biology; Medicine; Genetics; Pathology; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006234804,0.0006511357,0.001013267,0.001006735,0.0002191773,0.0009017328,0.000721084,0.001206163,0.001495935],"category_scores_gemma":[0.0007051667,0.0002217119,0.0002622283,0.00143066,0.0009051283,0.001003887,0.0006599466,0.001925587,0.0009281186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008544066,"about_ca_system_score_gemma":0.0009211645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111451,"about_ca_topic_score_gemma":0.002405735,"domain_scores_codex":[0.9998536,0.00002611878,0.00001686355,0.00002991042,0.00005714977,0.00001647628],"domain_scores_gemma":[0.9996494,0.0001665968,0.00004467698,0.00001300993,0.00009113305,0.00003517593],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001105036,0.00004707969,0.0004356572,0.005328376,0.00006873207,0.0002690449,0.00003542173,0.0005981563,0.004697202,0.01090136,0.03370407,0.9438044],"study_design_scores_gemma":[0.00001915522,0.00004119592,0.001530254,0.001338209,0.00008271277,0.001202664,0.00005028739,0.0001570887,0.0009909233,0.005659772,0.9889026,0.00002494701],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001369269,0.9979014,0.0002731379,0.0006874827,0.0002957202,0.000001687583,0.00001176393,0.000006728395,0.0006850801],"genre_scores_gemma":[0.0009100463,0.9977115,0.0002523287,0.0002935638,0.0003637067,0.000002804014,0.00001415828,0.000001299204,0.0004505279],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001495935,"threshold_uncertainty_score":0.006199181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01010341872798213,"score_gpt":0.2817340420049009,"score_spread":0.2716306232769187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}