{"id":"W2143683483","doi":"10.1016/j.molonc.2009.07.002","title":"Transcription factors down‐stream of Ras as molecular indicators for targeting malignancies with oncolytic herpes virus","year":2009,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Calgary","funders":"Flight Attendant Medical Research Institute","keywords":"Oncolytic virus; Biology; MAPK/ERK pathway; Transcription factor; Cancer research; Jurkat cells; Cancer cell; Permissiveness; Effector; Kinase; Raji cell; Lymphoma; Virology; Cell biology; Cancer; Gene; Immunology; Virus; Genetics; Viral replication; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002121298,0.0003649672,0.0003036374,0.0003721274,0.0001029694,0.0004147915,0.0001949711,0.0002167359,0.0007966225],"category_scores_gemma":[0.0001703858,0.0001548003,0.0002248619,0.0003217971,0.0001960338,0.0002884722,0.0002046649,0.0007485503,0.0002438872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002884051,"about_ca_system_score_gemma":0.0001572645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004234215,"about_ca_topic_score_gemma":0.0004705299,"domain_scores_codex":[0.9997583,0.00005322888,0.00001921761,0.00004142054,0.00008531988,0.00004252186],"domain_scores_gemma":[0.9998932,0.00002651826,0.00003075841,0.00001406116,0.00002144958,0.00001404822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008017316,0.00001916559,0.0001654357,0.00002651081,0.000002625392,0.00001254022,0.00001771064,0.00004208618,0.9986376,0.00005509217,0.00001164497,0.0009294805],"study_design_scores_gemma":[0.000003214103,0.0002042052,0.0008716004,0.000002877666,0.000009080699,0.00007091071,0.00001224239,0.0004138953,0.9975582,0.00001721105,0.0008339155,0.000002622787],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860792,0.004789087,0.006759584,0.00005865711,0.00004307005,0.00008258145,0.0003773733,0.00009463965,0.001715902],"genre_scores_gemma":[0.9815856,0.003380758,0.01152708,0.00002613813,0.00001335499,0.000100795,0.0006465478,0.00002615618,0.002693505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007966225,"threshold_uncertainty_score":0.002664924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112421942413402,"score_gpt":0.2968095788224844,"score_spread":0.2856853593983504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}