{"id":"W2143683483","doi":"10.1016/j.molonc.2009.07.002","title":"Transcription factors down‐stream of Ras as molecular indicators for targeting malignancies with oncolytic herpes virus","year":2009,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; University of Calgary","funders":"Flight Attendant Medical Research Institute","keywords":"Oncolytic virus; Biology; MAPK/ERK pathway; Transcription factor; Cancer research; Jurkat cells; Cancer cell; Permissiveness; Effector; Kinase; Raji cell; Lymphoma; Virology; Cell biology; Cancer; Gene; Immunology; Virus; Genetics; Viral replication; T cell; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004190204,0.0003682185,0.0004928251,0.0002457397,0.0001144214,0.00002076888,0.0004214699,0.0004241555,0.00004232822],"category_scores_gemma":[0.0001313536,0.0003295301,0.0002716032,0.0003380593,0.0002593094,0.000009494181,0.00004140673,0.0001607614,0.000005742971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001031738,"about_ca_system_score_gemma":0.0005553977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004521403,"about_ca_topic_score_gemma":0.00008251041,"domain_scores_codex":[0.9976526,0.0002562384,0.0004534332,0.0006379733,0.0003585184,0.0006412075],"domain_scores_gemma":[0.9988326,0.00003822388,0.0002475725,0.0004811789,0.000206875,0.0001935905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002948711,0.0003964367,0.0001842263,0.00003767404,0.0002033027,0.0000539257,0.0001885406,0.0004375325,0.9819242,0.0002465677,0.0002014615,0.01317739],"study_design_scores_gemma":[0.002100378,0.02114886,0.0003730052,0.00002219485,0.00008759979,0.00001837926,0.0001998072,0.00002270533,0.9620016,0.0003388712,0.01333306,0.0003535329],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885759,0.001723769,0.007402178,0.0004210972,0.00007331357,0.0009270509,0.00004394176,0.00003314158,0.0007995869],"genre_scores_gemma":[0.9965433,0.000135061,0.001886694,0.0008268068,0.00006233597,0.0001052063,0.0002706393,0.00006395279,0.0001060375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02075242,"threshold_uncertainty_score":0.9999157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01112421942413402,"score_gpt":0.2968095788224844,"score_spread":0.2856853593983504,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}