{"id":"W2143688669","doi":"10.1001/archneurol.2010.95","title":"Predictors of Parkin Mutations in Early-Onset Parkinson Disease","year":2010,"lang":"en","type":"article","venue":"Archives of Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institutes of Health; ACADIA Pharmaceuticals; Eisai; Valeant Pharmaceuticals International; GlaxoSmithKline; National Institute of Neurological Disorders and Stroke; Teva Pharmaceutical Industries; Parkinson's Disease Foundation; National Institute on Aging; Eli Lilly and Company; Pfizer; National Center for Research Resources; EMD Serono","keywords":"Parkin; Compound heterozygosity; Medicine; Odds ratio; Heterozygote advantage; Internal medicine; Confidence interval; Age of onset; Family history; Mutation; Genetics; Allele; Parkinson's disease; Disease; Biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004247129,0.0001149942,0.0002645404,0.0002552713,0.0000201361,0.000001643735,0.00009627362,0.00004666809,0.00004190044],"category_scores_gemma":[0.0001341032,0.0001036342,0.0001047502,0.0001064339,0.0002434757,0.00003032216,0.00004389602,0.000197764,0.000005264033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001667337,"about_ca_system_score_gemma":0.00008947265,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007224418,"about_ca_topic_score_gemma":0.00006600264,"domain_scores_codex":[0.9990917,0.000080895,0.0002608792,0.0002480424,0.0001207819,0.0001976877],"domain_scores_gemma":[0.9991463,0.0002255073,0.0001072625,0.0003051434,0.00001489868,0.0002008272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0012261,0.0006736839,0.9885325,0.00003928926,0.0000599638,0.0002293938,0.0002571499,0.00000940535,0.00695598,0.0003846194,0.00001572815,0.00161614],"study_design_scores_gemma":[0.001631256,0.0005936007,0.989288,0.00001595575,0.0001185417,0.00001810069,0.000004230186,0.0003044136,0.001747235,0.003766264,0.002456942,0.00005543333],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980329,0.00006951578,0.00002405143,0.0005786738,0.0001725623,0.000269312,0.0001290481,0.00001889839,0.0007049914],"genre_scores_gemma":[0.9992653,0.00004127591,0.0003795834,0.0001466511,0.00002976448,0.000036536,0.00005258337,0.00001566487,0.00003269877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005208745,"threshold_uncertainty_score":0.422608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009967850348911563,"score_gpt":0.2515200806853318,"score_spread":0.2415522303364202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}