{"id":"W2143694209","doi":"10.1093/hmg/ddl421","title":"The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Biology; Golgi apparatus; Gene isoform; Endoplasmic reticulum; Glycoprotein; Secretion; Cell biology; Extracellular; Secretory protein; Secretory pathway; Intracellular; Mutant; Glycosylation; Gene; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003391347,0.000316439,0.0001660652,0.00003227373,0.0005641774,0.0001315885,0.0006308563,0.0002136071,0.00002785688],"category_scores_gemma":[0.000008818884,0.0002278506,0.0002148281,0.0001768003,0.0001523283,0.000002422088,0.0001372157,0.000174422,0.00004039712],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002065819,"about_ca_system_score_gemma":0.00006283767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001163878,"about_ca_topic_score_gemma":0.000508347,"domain_scores_codex":[0.9981129,0.0001421289,0.0003259023,0.0005162171,0.0003828617,0.0005200373],"domain_scores_gemma":[0.9986206,0.00001192248,0.0001133921,0.001022676,0.0001137952,0.0001176511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004632939,0.00003828258,0.001561247,0.000008531446,0.00002828612,0.00001723801,0.00005181077,0.003410191,0.9939346,0.0001726506,0.0005591931,0.000171675],"study_design_scores_gemma":[0.0003958274,0.000270373,0.006551944,0.000006919321,0.00004765886,0.00001021277,0.00005786204,0.0002042075,0.8811984,0.0002644451,0.1106619,0.000330217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9385682,0.005752025,0.05324264,0.0002943427,0.0001415915,0.0006294561,0.00002598463,0.00002653785,0.001319175],"genre_scores_gemma":[0.9944623,0.0002447449,0.001377094,0.000327591,0.0002730233,0.0000447467,0.001362355,0.00007224711,0.001835862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1127361,"threshold_uncertainty_score":0.9291476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007833089259231004,"score_gpt":0.2127501904629011,"score_spread":0.2049171012036701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}