{"id":"W2143694209","doi":"10.1093/hmg/ddl421","title":"The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface","year":2006,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":114,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"","keywords":"Biology; Golgi apparatus; Gene isoform; Endoplasmic reticulum; Glycoprotein; Secretion; Cell biology; Extracellular; Secretory protein; Secretory pathway; Intracellular; Mutant; Glycosylation; Gene; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004116181,0.000716655,0.0002119498,0.0002818107,0.0001491729,0.0002471744,0.0001655205,0.000251925,0.001539884],"category_scores_gemma":[0.0001403364,0.00008280154,0.0001366505,0.000251057,0.0002848904,0.0001467252,0.0002185067,0.0002477163,0.001021454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003537745,"about_ca_system_score_gemma":0.0001840769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000601524,"about_ca_topic_score_gemma":0.0005773247,"domain_scores_codex":[0.9999512,0.000005043685,0.000003282095,0.00001094615,0.00001956436,0.000009850788],"domain_scores_gemma":[0.9999518,0.000007558284,0.00002007093,0.000002599256,0.000004816435,0.00001325705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001879213,0.00002758867,0.003584022,0.0001173961,0.00002261895,0.004200118,0.0001129381,0.000255504,0.9626493,0.0009941944,0.001116145,0.0267322],"study_design_scores_gemma":[0.0001663397,0.0006217804,0.0810238,0.0001025211,0.000144931,0.03767306,0.000343768,0.005227307,0.7669874,0.001829017,0.1058262,0.00005383568],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832231,0.004885541,0.006182353,0.0005572637,0.0000788914,0.00002724755,0.001364925,0.0004866752,0.003194106],"genre_scores_gemma":[0.9794565,0.003284681,0.003957595,0.0001319975,0.00003788072,0.00002657987,0.003266648,0.00005251799,0.009785736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001539884,"threshold_uncertainty_score":0.005151451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007833089259231004,"score_gpt":0.2127501904629011,"score_spread":0.2049171012036701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}