{"id":"W2143712580","doi":"10.1128/ec.3.1.190-199.2004","title":"<i>Candida albicans</i> Lacking the Gene Encoding the Regulatory Subunit of Protein Kinase A Displays a Defect in Hyphal Formation and an Altered Localization of the Catalytic Subunit","year":2004,"lang":"en","type":"article","venue":"Eukaryotic Cell","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Medical Research Council Canada; Medical Research Council; Universidad de Buenos Aires; Agencia Nacional de Promoción Científica y Tecnológica; Consejo Nacional de Investigaciones Científicas y Técnicas","keywords":"Biology; Protein kinase A; Protein subunit; Candida albicans; Fusion protein; Mutant; Cyclin-dependent kinase complex; Molecular biology; Mitogen-activated protein kinase kinase; Cell biology; Biochemistry; Kinase; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004964854,0.0005364763,0.0001866184,0.000309118,0.0002175857,0.0005110935,0.0003073021,0.0002956229,0.001167464],"category_scores_gemma":[0.00008998987,0.0001390769,0.0002183794,0.0002826904,0.0002386502,0.0001376797,0.0002605052,0.0004927165,0.0005299847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003438978,"about_ca_system_score_gemma":0.0002527729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002634832,"about_ca_topic_score_gemma":0.003464262,"domain_scores_codex":[0.9998487,0.000008495365,0.00001496553,0.00003353953,0.00006409688,0.00003003865],"domain_scores_gemma":[0.9999158,0.000008116107,0.00003008471,0.00001153092,0.00001166947,0.00002274103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002767868,0.000008944561,0.0002566879,0.00001737898,0.000002240721,0.00007964746,0.000003078957,0.00002091437,0.9989555,0.00004653639,0.00006873903,0.0005126427],"study_design_scores_gemma":[0.000005629873,0.00004746436,0.01090017,0.000006085219,0.00001106442,0.001158709,0.00002358737,0.0005058999,0.984776,0.00003294451,0.002524934,0.000007634359],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9912359,0.001089225,0.002313561,0.0001360811,0.00003924773,0.00002605069,0.002558763,0.0001880385,0.002413322],"genre_scores_gemma":[0.9879793,0.0007052965,0.004287863,0.0001010764,0.00001237849,0.000037056,0.004025424,0.00008335056,0.002768279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002634832,"threshold_uncertainty_score":0.00523895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0139482067084353,"score_gpt":0.2403529485248805,"score_spread":0.2264047418164452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}