{"id":"W2143717535","doi":"10.1096/fj.11-184911","title":"Specialization of endoplasmic reticulum chaperones for the folding and function of myelin glycoproteins P0 and PMP22","year":2011,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Hereditary Neurological Disorders","field":"Neuroscience","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Alberta Innovates - Health Solutions","keywords":"Calnexin; Calreticulin; Endoplasmic reticulum; Myelin; Cell biology; Peripheral myelin protein 22; Glycoprotein; Protein disulfide-isomerase; Chaperone (clinical); Protein folding; Unfolded protein response; Function (biology); Biology; Chemistry; Biochemistry; Neuroscience; Medicine; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003373322,0.00006875437,0.00009868974,0.00003562187,0.0002160299,0.00001477238,0.0001304312,0.00003036677,0.000090348],"category_scores_gemma":[0.0005429226,0.00003649377,0.00003603938,0.00008860141,0.0002589106,0.0001084281,0.0000384386,0.0001172845,7.852277e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003275112,"about_ca_system_score_gemma":0.00001304296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001189466,"about_ca_topic_score_gemma":0.000007540511,"domain_scores_codex":[0.9993029,0.0001209543,0.0002021818,0.0001086437,0.00014478,0.0001205106],"domain_scores_gemma":[0.9993322,0.000328944,0.000177492,0.00009407604,0.00003432916,0.00003290692],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003898331,0.0000383906,0.001283997,0.0000185431,0.000008916802,0.0000023391,0.0008930476,0.00005241425,0.9864119,0.004086044,0.00005287679,0.006761657],"study_design_scores_gemma":[0.0007821165,0.00101767,0.01841044,0.00002456749,0.00006613725,0.0001430129,0.0005624552,0.00339014,0.9651999,0.01003805,0.0002868319,0.00007863819],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940588,0.0001689383,0.004635515,0.0003807489,0.0002487802,0.0002686023,0.000007903916,0.000006492307,0.0002242282],"genre_scores_gemma":[0.9991423,0.0004704371,0.00008426856,0.0001704962,0.0001012949,0.000005225218,1.784143e-7,0.000006960574,0.00001878265],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.021212,"threshold_uncertainty_score":0.1661549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06036631801819162,"score_gpt":0.2354679886707087,"score_spread":0.1751016706525171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}