{"id":"W2143722956","doi":"10.1021/bi9001826","title":"Structure of the Inhibitor W7 Bound to the Regulatory Domain of Cardiac Troponin C","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute; University of Alberta; National Institutes of Health; University of Georgia; Uppsala Universitet; Fondation pour la Recherche Médicale; Canadian Institutes of Health Research; Ryerson University","keywords":"Troponin C; Chemistry; Conformational isomerism; Docking (animal); Calmodulin; Allosteric regulation; Protein structure; Troponin I; Stereochemistry; Biophysics; Biochemistry; Receptor; Biology; Cardiology; Medicine; Enzyme; Molecule","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009318529,0.0002013111,0.0003442424,0.00009819411,0.0002682891,0.0002039321,0.0007161601,0.0003593188,0.001330854],"category_scores_gemma":[0.0001897817,0.0001425305,0.0001922913,0.00008920368,0.0002233082,0.0002094928,0.0001166655,0.0005689394,0.0002040965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006382497,"about_ca_system_score_gemma":0.0004767172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004130726,"about_ca_topic_score_gemma":0.003108923,"domain_scores_codex":[0.9999334,0.0000101493,0.000001856497,0.00001193651,0.00002677717,0.00001586005],"domain_scores_gemma":[0.9999508,0.0000141536,0.00001163073,0.000003569855,0.000009207273,0.00001064644],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000983797,0.0002670424,0.001767092,0.0001815937,0.00008538931,0.001059562,0.0001196145,0.0291361,0.9510401,0.003611555,0.001312105,0.01043589],"study_design_scores_gemma":[0.0004958893,0.001881568,0.0114506,0.00004830338,0.0001342421,0.000903946,0.0001921577,0.3858838,0.5856948,0.001099648,0.01212735,0.00008771498],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940754,0.0008449639,0.002487357,0.0001562764,0.00001761558,0.00002185639,0.0001704131,0.00005611053,0.002169895],"genre_scores_gemma":[0.9916165,0.0006581433,0.004659404,0.00009236466,0.000006143545,0.00001984905,0.001281458,0.00002642648,0.001639636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004130726,"threshold_uncertainty_score":0.008213341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004159756177200991,"score_gpt":0.2237775286759237,"score_spread":0.2196177724987227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}