{"id":"W2143743183","doi":"10.1038/mt.2010.85","title":"Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Encana (Canada)","funders":"Alnylam Pharmaceuticals","keywords":"Asialoglycoprotein receptor; Apolipoprotein E; LDL receptor; In vivo; Endogeny; Receptor; In vitro; Small interfering RNA; Cell biology; Ligand (biochemistry); Chemistry; RNA interference; Biology; Lipoprotein; Biochemistry; Transfection; Hepatocyte; Cholesterol; RNA; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004587555,0.0004801199,0.0004021836,0.0003397298,0.0001573915,0.0004443696,0.0003367878,0.000518624,0.0004946581],"category_scores_gemma":[0.0002475471,0.0001872328,0.0004153894,0.0001526383,0.0004306739,0.0004178237,0.0003556123,0.0004142067,0.0003121328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005364771,"about_ca_system_score_gemma":0.0003685447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003142971,"about_ca_topic_score_gemma":0.0004313242,"domain_scores_codex":[0.9996643,0.00006323156,0.00004369109,0.00008279228,0.00009344466,0.00005248969],"domain_scores_gemma":[0.9998698,0.00002690923,0.00004746489,0.00001543276,0.00002315485,0.00001729176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004419555,0.00001454298,0.00008231406,0.0001004893,0.000008645789,0.00004231721,0.00001459602,0.00008935634,0.9957381,0.0004962503,0.00002881284,0.003340411],"study_design_scores_gemma":[0.00001094489,0.0001951428,0.0002756399,0.000006081762,0.00002289099,0.0001257814,0.00000770689,0.0007609837,0.9957592,0.00005815427,0.002770635,0.000006860143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8738841,0.01588015,0.1022772,0.0004094993,0.0002019377,0.0003535232,0.0003899591,0.0006561988,0.005947487],"genre_scores_gemma":[0.9451118,0.004705091,0.04387918,0.0002787104,0.0000451206,0.0002970877,0.0003899405,0.00005905575,0.005234107],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005364771,"threshold_uncertainty_score":0.003892422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282517653924593,"score_gpt":0.2131286059002929,"score_spread":0.200303429361047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}