{"id":"W2143743183","doi":"10.1038/mt.2010.85","title":"Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1215,"is_retracted":false,"has_abstract":true,"ca_institutions":"Encana (Canada)","funders":"Alnylam Pharmaceuticals","keywords":"Asialoglycoprotein receptor; Apolipoprotein E; LDL receptor; In vivo; Endogeny; Receptor; In vitro; Small interfering RNA; Cell biology; Ligand (biochemistry); Chemistry; RNA interference; Biology; Lipoprotein; Biochemistry; Transfection; Hepatocyte; Cholesterol; RNA; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048996,0.0002168466,0.0001877627,0.00005814617,0.00006551141,0.00002207976,0.0002149729,0.0001777655,0.00001750892],"category_scores_gemma":[0.000004151465,0.0001755825,0.0000858899,0.00007934263,0.0001258312,0.000003565789,0.00003171577,0.00013039,0.000003196687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000345635,"about_ca_system_score_gemma":0.0001053995,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004361048,"about_ca_topic_score_gemma":0.00003261739,"domain_scores_codex":[0.9990605,0.00004345607,0.0001720115,0.0003240144,0.0001600946,0.0002399144],"domain_scores_gemma":[0.9992263,0.000008493823,0.00009385448,0.0004433655,0.0001576015,0.00007041373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004005734,0.0001105068,0.0003136029,0.000007785397,0.0001663363,0.00002697133,0.00006772925,0.00003511977,0.9928255,0.00008374018,0.000007390724,0.005954713],"study_design_scores_gemma":[0.001140775,0.001614131,0.0002317561,0.000008523871,0.00002637911,0.00005534656,0.00003619349,0.00005807483,0.9952241,0.0001788805,0.001194942,0.000230892],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890405,0.002193097,0.008176698,0.00006201652,0.0000890499,0.0002326544,0.00001720758,0.00001528648,0.0001734853],"genre_scores_gemma":[0.9950995,0.0005297997,0.002968775,0.001214801,0.00003599446,0.00002055713,0.00004984759,0.00004210656,0.00003856276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006059052,"threshold_uncertainty_score":0.7160047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282517653924593,"score_gpt":0.2131286059002929,"score_spread":0.200303429361047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}