{"id":"W2143804728","doi":"10.1677/jme.0.0320843","title":"Intramolecular interactions between the AF3 domain and the C-terminus of the human progesterone receptor are mediated through two LXXLL motifs","year":2004,"lang":"en","type":"article","venue":"Journal of Molecular Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Transactivation; Cell biology; Gene isoform; Progesterone receptor; Coactivator; Transcription factor; Nuclear receptor coactivator 1; Medicine; Gene; Biology; Genetics; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002915125,0.000219308,0.0003686603,0.00005074874,0.0001973138,0.00002503286,0.0005674756,0.0001367547,0.000005351642],"category_scores_gemma":[0.0001840917,0.0001093338,0.0002992542,0.0001475192,0.0008560857,0.000008695252,0.0002525988,0.0006539389,0.000002569599],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003008037,"about_ca_system_score_gemma":0.00009017465,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003077528,"about_ca_topic_score_gemma":0.00001175409,"domain_scores_codex":[0.9981194,0.000580117,0.0005468575,0.0002088785,0.0002286809,0.0003161373],"domain_scores_gemma":[0.998541,0.00007692225,0.0006963112,0.0004639351,0.0001577043,0.00006414701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001740746,0.0001039183,0.001881971,0.00001745054,0.0008008619,0.0001329543,0.000387068,0.0001808162,0.9936471,0.002039962,0.0001762275,0.0004575939],"study_design_scores_gemma":[0.006838129,0.0007015867,0.003413213,0.000115033,0.0003700973,0.002756462,0.0004289008,0.000002166892,0.9761896,0.003524754,0.005453749,0.0002063618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888381,0.003775429,0.0009386272,0.005609882,0.0002695044,0.0003779751,0.000009670079,0.000004492791,0.0001762601],"genre_scores_gemma":[0.998625,0.0003014584,0.0004018251,0.0004141183,0.0001825631,0.00001428363,0.000009052664,0.00002756094,0.00002416021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01745756,"threshold_uncertainty_score":0.4458505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007197979597417956,"score_gpt":0.26111525399456,"score_spread":0.253917274397142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}