{"id":"W2143866789","doi":"10.1093/annonc/mdv027","title":"A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Amgen","keywords":"Medicine; Gemcitabine; Placebo; Internal medicine; Metastatic adenocarcinoma; Oncology; Double blind; Randomized controlled trial; Pancreatic ductal adenocarcinoma; Adenocarcinoma; Pancreatic cancer; Chemotherapy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008692187,0.0002539801,0.003203482,0.0002855807,0.00006828615,0.000006417475,0.0003499082,0.0002122748,0.0001116353],"category_scores_gemma":[0.005548762,0.0001124809,0.0004153236,0.0004494778,0.000899981,0.00007194167,0.00005320185,0.0003063561,0.000002347836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007599458,"about_ca_system_score_gemma":0.003077607,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004725021,"about_ca_topic_score_gemma":0.000419702,"domain_scores_codex":[0.9955065,0.001663733,0.001525277,0.0002765296,0.0006366301,0.0003913614],"domain_scores_gemma":[0.9881718,0.008837872,0.001226672,0.0005104982,0.001117377,0.0001357431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9831769,0.009416869,0.0002315823,0.0001077647,0.001633392,0.00002128136,0.001634537,0.00001669838,0.00006919864,0.0009828794,0.000612221,0.002096683],"study_design_scores_gemma":[0.89473,0.09893993,0.00004544124,0.00009546324,0.001099155,0.00004757634,0.0006718572,0.001402719,0.0009438049,0.001429014,0.0005003839,0.00009459764],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571741,0.0007318601,0.0002536482,0.0110824,0.0002193355,0.02897644,0.00001978823,0.000009049568,0.001533428],"genre_scores_gemma":[0.9931583,0.0005246424,0.000366299,0.0003139343,0.0001868205,0.004524271,0.00002537606,0.00002709347,0.0008733012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08952306,"threshold_uncertainty_score":0.6642787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2032388795859554,"score_gpt":0.4526389458185294,"score_spread":0.249400066232574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}