{"id":"W2143866789","doi":"10.1093/annonc/mdv027","title":"A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial","year":2015,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":164,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Cancer Institute; Amgen","keywords":"Medicine; Gemcitabine; Placebo; Internal medicine; Metastatic adenocarcinoma; Oncology; Double blind; Randomized controlled trial; Pancreatic ductal adenocarcinoma; Adenocarcinoma; Pancreatic cancer; Chemotherapy; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001735208,0.002493488,0.004847617,0.0005336269,0.0004908497,0.001369411,0.001298983,0.002361879,0.007746291],"category_scores_gemma":[0.00213893,0.0008213001,0.002688228,0.0004682861,0.001952327,0.00134589,0.000540244,0.004579858,0.001492196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053235,"about_ca_system_score_gemma":0.001241856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001002633,"about_ca_topic_score_gemma":0.001904184,"domain_scores_codex":[0.9993674,0.0003661653,0.00003012814,0.0001202502,0.00003080792,0.00008517956],"domain_scores_gemma":[0.9991856,0.0002861362,0.0001722047,0.00008034256,0.00004014204,0.0002355109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9887404,0.001663928,0.0001628381,0.0005155723,0.0008682421,0.00002233674,0.00002710714,0.0002388653,0.001103702,0.00009042335,0.0005864078,0.005980116],"study_design_scores_gemma":[0.9854914,0.01336059,0.0002907437,0.00002012069,0.0002723588,0.00001324175,0.000009755526,0.0001066069,0.0001060438,0.00008821628,0.0002332534,0.000007688291],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680732,0.01564788,0.001450989,0.001879102,0.001842858,0.005414018,0.001552484,0.0003662494,0.003773275],"genre_scores_gemma":[0.9759269,0.007326337,0.001893007,0.002980632,0.0007992031,0.005046886,0.001360264,0.00007163228,0.004595102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007746291,"threshold_uncertainty_score":0.02591389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2032388795859554,"score_gpt":0.4526389458185294,"score_spread":0.249400066232574,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}