{"id":"W2143881247","doi":"10.1371/journal.pcbi.1000578","title":"A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen","year":2009,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Mitacs","keywords":"Antigen; Receptor; Context (archaeology); Cell biology; T cell; T-cell receptor; Biology; Cell; Antigen-presenting cell; B-cell receptor; Immune system; B cell; Immunology; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000147329,0.00008990237,0.0001545576,0.000223229,0.0001047402,0.000008986137,0.00006041222,0.0001226886,0.0001440021],"category_scores_gemma":[0.0001008009,0.00008672167,0.00002946371,0.00009412051,0.00003013131,0.000052395,0.00001984971,0.0001058498,0.0001481435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002875922,"about_ca_system_score_gemma":0.00002941375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001229343,"about_ca_topic_score_gemma":0.000001768757,"domain_scores_codex":[0.9992758,0.00008907497,0.0002049343,0.0002262902,0.00001173905,0.0001921863],"domain_scores_gemma":[0.9995068,0.0003004939,0.00005278628,0.00006320013,0.00006252287,0.00001417531],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001178183,0.0001619864,0.004195182,0.000005943845,0.00002493438,5.014929e-7,0.0003645035,0.0002706782,0.9835753,0.002018795,0.004158117,0.004045898],"study_design_scores_gemma":[0.007508605,0.006297307,0.2316319,0.0001178915,0.00004246492,0.0001140899,0.000940879,0.003341135,0.3474744,0.02107542,0.3805689,0.00088699],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941012,0.001042473,0.00150274,0.001225114,0.0004455717,0.0003373289,0.00001063941,0.00004278348,0.001292209],"genre_scores_gemma":[0.9950237,0.0000304598,0.001665159,0.001241878,0.00002186079,0.00002289231,0.0002189789,0.000005692206,0.001769342],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6361009,"threshold_uncertainty_score":0.3536407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677494898924583,"score_gpt":0.2563404215884295,"score_spread":0.2395654725991837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}