{"id":"W2143881247","doi":"10.1371/journal.pcbi.1000578","title":"A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen","year":2009,"lang":"en","type":"article","venue":"PLoS Computational Biology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Mitacs","keywords":"Antigen; Receptor; Context (archaeology); Cell biology; T cell; T-cell receptor; Biology; Cell; Antigen-presenting cell; B-cell receptor; Immune system; B cell; Immunology; Antibody; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009039079,0.0009012427,0.001278983,0.0003713757,0.0005489138,0.001231359,0.001641596,0.001940376,0.002969002],"category_scores_gemma":[0.002678214,0.0008003574,0.0009371628,0.0002349875,0.001139705,0.003687645,0.001095213,0.001047489,0.000757508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008566121,"about_ca_system_score_gemma":0.0008625441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001172916,"about_ca_topic_score_gemma":0.000723761,"domain_scores_codex":[0.999507,0.0001017663,0.00002065287,0.000150702,0.00008644138,0.0001336085],"domain_scores_gemma":[0.9989964,0.000479954,0.0001437101,0.0001936662,0.00006303499,0.0001232623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0008258945,0.0003552862,0.002412873,0.0005127485,0.00007479428,0.001236169,0.0002240106,0.3990214,0.5115707,0.0583684,0.0005577979,0.02484001],"study_design_scores_gemma":[0.0001426685,0.0003010301,0.001280513,0.0000184116,0.00005412389,0.0004603677,0.00006937281,0.9152081,0.06305843,0.01817663,0.001160117,0.00007026156],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7259997,0.00100193,0.26627,0.0006883258,0.00007660218,0.00009076872,0.00006427382,0.0009136502,0.004894761],"genre_scores_gemma":[0.9813516,0.0003177532,0.01631413,0.00008232869,0.00001739711,0.00007235189,0.0000387285,0.00009001076,0.001715777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002969002,"threshold_uncertainty_score":0.00993228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01677494898924583,"score_gpt":0.2563404215884295,"score_spread":0.2395654725991837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}