{"id":"W2143896637","doi":"10.1093/nar/gku206","title":"Functional redundancy between the transcriptional activation domains of E2A is mediated by binding to the KIX domain of CBP/p300","year":2014,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Transcription factor; CREB-binding protein; DNA-binding protein; Activator (genetics); Cell biology; Carcinogenesis; Plasma protein binding; HEK 293 cells; Transcription (linguistics); Genetics; Molecular biology; Gene; CREB","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849933,0.0004839372,0.0003050591,0.0002969571,0.0001802296,0.0004739571,0.0004730312,0.0002445234,0.002023171],"category_scores_gemma":[0.0002486911,0.0002331032,0.0003914958,0.0002115039,0.0002656871,0.0002622888,0.0004185492,0.0005452725,0.00100976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331542,"about_ca_system_score_gemma":0.0002957625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004178488,"about_ca_topic_score_gemma":0.0004596495,"domain_scores_codex":[0.9997302,0.00004170851,0.00002251544,0.00005916255,0.00007289933,0.00007352435],"domain_scores_gemma":[0.9997972,0.00004798332,0.00004131272,0.00004737954,0.00002212218,0.00004390717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009800097,0.00003074233,0.0007509529,0.00002870363,0.000008931267,0.0001105787,0.00001632031,0.00005910116,0.996614,0.0002615695,0.00002786164,0.001993234],"study_design_scores_gemma":[0.00002866999,0.0002381322,0.01650713,0.000006905937,0.00003135968,0.002445202,0.00004825502,0.001218062,0.9738827,0.0002188853,0.005362539,0.00001212638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927782,0.001371749,0.004263115,0.00007490817,0.00001583032,0.00001685766,0.0001630436,0.00007142683,0.001244754],"genre_scores_gemma":[0.9969125,0.0002008283,0.0016113,0.00002468712,0.000006556176,0.00001025235,0.0003720841,0.000008122067,0.0008537316],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002023171,"threshold_uncertainty_score":0.006768167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03938554516068626,"score_gpt":0.3008713880762114,"score_spread":0.2614858429155252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}