{"id":"W2143903334","doi":"10.4049/jimmunol.1000008","title":"Fine Tuning of the Threshold of T Cell Selection by the Nck Adapters","year":2010,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"T-cell receptor; Avidity; Thymocyte; Signal transducing adaptor protein; Negative selection; Biology; Context (archaeology); Major histocompatibility complex; T cell; Repertoire; Cell biology; Clonal deletion; CD8; Immunology; Antigen; Cancer research; Signal transduction; Genetics; Immune system; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002803162,0.0002395676,0.0003032392,0.0002531332,0.0001879375,0.000646283,0.0003138458,0.0002936543,0.0006786353],"category_scores_gemma":[0.0004814918,0.0001268242,0.0001110745,0.0001354841,0.0002474166,0.0004108278,0.000434276,0.0004186552,0.0003254163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003842784,"about_ca_system_score_gemma":0.0002411626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003393274,"about_ca_topic_score_gemma":0.0006803643,"domain_scores_codex":[0.9997008,0.00003689271,0.00003851316,0.00006178903,0.0000805827,0.00008148595],"domain_scores_gemma":[0.9995607,0.00006899404,0.0001340148,0.00006292232,0.000069128,0.0001042839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005798006,0.000006469621,0.0004524132,0.00001139605,0.00000195162,0.00002406297,0.000004562229,0.00007318023,0.9980867,0.0001259053,0.00000948756,0.001146061],"study_design_scores_gemma":[0.00001627411,0.00007451936,0.009680897,0.000008635338,0.0000180599,0.000436588,0.00003410909,0.00540918,0.9828278,0.0002031413,0.001282013,0.00000890371],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938745,0.0008743312,0.004205916,0.00006670387,0.00001328771,0.000009348876,0.00004545153,0.000056219,0.0008541898],"genre_scores_gemma":[0.9971262,0.0002388762,0.002124632,0.00002325885,0.000007565696,0.000007716571,0.00005189401,0.00001467228,0.0004050504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006786353,"threshold_uncertainty_score":0.002788067,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008181485799668584,"score_gpt":0.2029833293840272,"score_spread":0.1948018435843586,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}