{"id":"W2143909597","doi":"10.1002/etc.374","title":"Reverse engineering adverse outcome pathways","year":2010,"lang":"en","type":"article","venue":"Environmental Toxicology and Chemistry","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Environment and Climate Change Canada","funders":"Natural Environment Research Council; Sight Research UK","keywords":"Adverse Outcome Pathway; Flutamide; Adverse effect; Biology; Computational biology; Stressor; Biological pathway; Organism; Bioinformatics; Gene; Gene expression; Neuroscience; Pharmacology; Genetics; Prostate cancer; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001118599,0.0008501091,0.000556113,0.0007934512,0.0003527971,0.0008819632,0.0007450549,0.0005149483,0.002307149],"category_scores_gemma":[0.002147011,0.0004066828,0.001214076,0.0007751309,0.0004474161,0.0008067845,0.0009411129,0.001326503,0.0006890157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005975529,"about_ca_system_score_gemma":0.0009740855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00108725,"about_ca_topic_score_gemma":0.002189192,"domain_scores_codex":[0.9994152,0.0001228643,0.00004059314,0.0002050387,0.0001443608,0.00007190117],"domain_scores_gemma":[0.9984652,0.0005971754,0.0003886904,0.0002841114,0.0002067185,0.00005801156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0005090901,0.0003199677,0.0113968,0.001177264,0.0003579228,0.0008090359,0.0002236088,0.07632767,0.7444228,0.04227633,0.001672392,0.1205072],"study_design_scores_gemma":[0.000118202,0.001023163,0.01202652,0.0001502021,0.0006576728,0.001340003,0.0003932173,0.3397793,0.502591,0.07424818,0.06755216,0.0001203469],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.280319,0.001220989,0.7016725,0.0009102142,0.0002505857,0.000708033,0.00441248,0.002122952,0.008383243],"genre_scores_gemma":[0.5682769,0.00251932,0.4110584,0.0006060665,0.00005348623,0.0008461597,0.009059193,0.0003820843,0.007198262],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.002307149,"threshold_uncertainty_score":0.007718146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003771618729669012,"score_gpt":0.1777456506126516,"score_spread":0.1739740318829826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}