{"id":"W2143910928","doi":"10.2337/db12-0256","title":"Loss of TDAG51 Results in Mature-Onset Obesity, Hepatic Steatosis, and Insulin Resistance by Regulating Lipogenesis","year":2012,"lang":"en","type":"article","venue":"Diabetes","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; St. Joseph’s Healthcare Hamilton","funders":"Canadian Institutes of Health Research; Amgen; Amgen Canada; McMaster University; University of Pennsylvania; National Institute of Diabetes and Digestive and Kidney Diseases; Heart and Stroke Foundation of Canada","keywords":"Lipogenesis; Internal medicine; Endocrinology; Steatosis; Insulin resistance; Adipogenesis; Biology; Fatty liver; Adipocyte; Lipid metabolism; Adipose tissue; Insulin; White adipose tissue; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009033697,0.0004142541,0.0002545922,0.0002928977,0.0001556831,0.0002586571,0.000191416,0.0003333449,0.001970234],"category_scores_gemma":[0.0001061524,0.0001690211,0.0003586304,0.0001993615,0.000260574,0.0001895661,0.0002239231,0.0004923651,0.0006017192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000179051,"about_ca_system_score_gemma":0.0001119279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003031242,"about_ca_topic_score_gemma":0.0005280255,"domain_scores_codex":[0.9998915,0.00001372976,0.00002175133,0.00003141087,0.00002149771,0.00002021866],"domain_scores_gemma":[0.9998393,0.00001928199,0.00006910693,0.00001983201,0.000009699255,0.00004282889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002396416,0.0000325503,0.000603303,0.00003612558,0.00001202321,0.0002326668,0.000006095036,0.0001030314,0.9969983,0.0001054279,0.00008238923,0.001548416],"study_design_scores_gemma":[0.0001123669,0.0007358011,0.03728985,0.00002445137,0.00009712815,0.003243245,0.00007852696,0.002655115,0.9497977,0.0002578569,0.005688474,0.00001939767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913409,0.002161263,0.004032886,0.0001688932,0.00007045121,0.00002954665,0.001022219,0.0001698374,0.001003919],"genre_scores_gemma":[0.9932212,0.001031463,0.001710374,0.0000826129,0.00001157737,0.00004511307,0.000848426,0.00003748296,0.003011759],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001970234,"threshold_uncertainty_score":0.006591082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008124003210414073,"score_gpt":0.2440411968648309,"score_spread":0.2359171936544168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}