{"id":"W2143918910","doi":"10.1111/bcpt.12492","title":"Relationships between Endogenous Plasma Biomarkers of Constitutive Cytochrome <scp>P</scp>450 3<scp>A</scp> Activity and Single‐Time‐Point Oral Midazolam Microdose Phenotype in Healthy Subjects","year":2015,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; London Health Sciences Centre","keywords":"MicroDose; CYP3A; Midazolam; Endogeny; Pharmacology; Pharmacokinetics; Endocrinology; Oral administration; Basal (medicine); Chemistry; Internal medicine; In vivo; Cytochrome P450; Medicine; Metabolism; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003706429,0.0002536587,0.0003558083,0.0003524581,0.0001560221,0.0004319066,0.0001174912,0.0004072286,0.000726554],"category_scores_gemma":[0.001020976,0.00021565,0.0002100272,0.0003168719,0.0002451929,0.0001620633,0.0001998911,0.0002991417,0.0001703478],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001526654,"about_ca_system_score_gemma":0.00009948961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001199541,"about_ca_topic_score_gemma":0.001313297,"domain_scores_codex":[0.999653,0.00009945084,0.00003159648,0.0001250078,0.00005813665,0.00003278171],"domain_scores_gemma":[0.9993192,0.0001613258,0.0003178511,0.0000791046,0.00005429888,0.00006820654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003448179,0.00008218196,0.9650086,0.00003149078,0.0002250962,0.000273821,0.0001463669,0.000109358,0.02487226,0.00003512444,0.00007531464,0.005692314],"study_design_scores_gemma":[0.00001024977,0.0003093083,0.9982914,0.000001247676,0.000029987,0.0002984682,0.00003160422,0.0001728994,0.0007818576,0.00001912975,0.00005142577,0.000002366084],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993788,0.0002610988,0.0001446213,0.000009514004,0.000001485736,0.00000489288,0.0001039464,0.00000547708,0.00009021007],"genre_scores_gemma":[0.9996114,0.00005158411,0.0001297797,0.00001102022,0.000002630931,0.000004625546,0.0001053952,0.000002268099,0.00008130116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001199541,"threshold_uncertainty_score":0.002430558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2766665519382691,"score_gpt":0.4385634322602433,"score_spread":0.1618968803219742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}