{"id":"W2143918910","doi":"10.1111/bcpt.12492","title":"Relationships between Endogenous Plasma Biomarkers of Constitutive Cytochrome <scp>P</scp>450 3<scp>A</scp> Activity and Single‐Time‐Point Oral Midazolam Microdose Phenotype in Healthy Subjects","year":2015,"lang":"en","type":"article","venue":"Basic & Clinical Pharmacology & Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; London Health Sciences Centre","keywords":"MicroDose; CYP3A; Midazolam; Endogeny; Pharmacology; Pharmacokinetics; Endocrinology; Oral administration; Basal (medicine); Chemistry; Internal medicine; In vivo; Cytochrome P450; Medicine; Metabolism; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.008834279,0.001044892,0.002662143,0.0008748416,0.0005004411,0.00003650332,0.0009973061,0.002564982,0.0002237164],"category_scores_gemma":[0.006461065,0.001118652,0.0004516947,0.001162499,0.004233704,0.0003670903,0.0008358929,0.004594496,0.0003875038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004412851,"about_ca_system_score_gemma":0.001873268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009413082,"about_ca_topic_score_gemma":0.0001316903,"domain_scores_codex":[0.9829267,0.009954711,0.002688309,0.00180677,0.0004551029,0.002168456],"domain_scores_gemma":[0.9696839,0.02560692,0.001514497,0.0005527165,0.000525615,0.002116312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002634138,0.006939784,0.1544188,0.0001948258,0.002629854,0.0007190817,0.003038138,0.000475305,0.7893375,0.0003804663,0.02817498,0.01105713],"study_design_scores_gemma":[0.07216142,0.008521482,0.2461792,0.00008618064,0.005271605,0.0006404819,0.0017279,0.003993318,0.4484302,0.003656593,0.20821,0.001121686],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978299,0.003282955,0.00007910976,0.001209648,0.005312882,0.002550976,0.0005524013,0.0002036496,0.00850936],"genre_scores_gemma":[0.9919848,0.001150591,0.0008183108,0.004104911,0.001217726,0.0002161653,0.0001034558,0.0001197331,0.0002842922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3409073,"threshold_uncertainty_score":0.9991264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2766665519382691,"score_gpt":0.4385634322602433,"score_spread":0.1618968803219742,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}