{"id":"W2143949552","doi":"10.1002/cmdc.201500287","title":"Design, Synthesis, and Evaluation of an <sup>18</sup>F‐Labeled Radiotracer Based on Celecoxib–NBD for Positron Emission Tomography (PET) Imaging of Cyclooxygenase‐2 (COX‐2)","year":2015,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"Positron emission tomography; In vivo; Celecoxib; Chemistry; Cyclooxygenase; In vitro; Nuclear medicine; Enzyme; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002941188,0.0002788769,0.0005651258,0.0002809517,0.00005327604,0.00001119931,0.0001112519,0.0001269877,0.00004357208],"category_scores_gemma":[0.00102024,0.0002381606,0.0001379502,0.0002381986,0.0001119957,0.0001370755,0.00001783625,0.0001480216,0.00000136642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001437712,"about_ca_system_score_gemma":0.0003758931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001276116,"about_ca_topic_score_gemma":6.034667e-7,"domain_scores_codex":[0.9978328,0.000223065,0.000451107,0.0004006185,0.0007567672,0.0003355962],"domain_scores_gemma":[0.9978012,0.0005090506,0.0002608946,0.0004481815,0.0005874134,0.0003932213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003656303,0.00079603,0.006333681,0.001138959,0.0001306207,0.00002009087,0.0007646443,0.00106977,0.9498202,0.000009750263,0.003500285,0.03275971],"study_design_scores_gemma":[0.004373602,0.0004453325,0.001588675,0.0003307862,0.0004166967,0.00001321524,0.0001178317,0.2650932,0.7273495,0.00005591428,0.00005119444,0.0001640271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961156,0.0008793349,0.0008641443,0.0001667518,0.00007681083,0.001536985,0.0000130145,0.0000486333,0.0002987378],"genre_scores_gemma":[0.9937949,0.00001168748,0.005570156,0.0001038521,0.000187679,0.0002020782,0.00005452771,0.00005569202,0.00001940669],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2640235,"threshold_uncertainty_score":0.9711907,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03810206190235645,"score_gpt":0.3013347297914563,"score_spread":0.2632326678890999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}