{"id":"W2143949552","doi":"10.1002/cmdc.201500287","title":"Design, Synthesis, and Evaluation of an <sup>18</sup>F‐Labeled Radiotracer Based on Celecoxib–NBD for Positron Emission Tomography (PET) Imaging of Cyclooxygenase‐2 (COX‐2)","year":2015,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; University of Alberta; Alberta Cancer Foundation","keywords":"Positron emission tomography; In vivo; Celecoxib; Chemistry; Cyclooxygenase; In vitro; Nuclear medicine; Enzyme; Medicine; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003018884,0.0005324297,0.000400851,0.0002192586,0.0002086852,0.0004414406,0.000671345,0.0004463064,0.001216849],"category_scores_gemma":[0.0001667354,0.0002735774,0.0003461633,0.0002468033,0.0002698849,0.0003103003,0.0002079499,0.0003640524,0.0008853361],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004950985,"about_ca_system_score_gemma":0.0005967151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001004076,"about_ca_topic_score_gemma":0.001169125,"domain_scores_codex":[0.9998717,0.00002135714,0.0000137081,0.00002773224,0.00003616322,0.00002933791],"domain_scores_gemma":[0.9998773,0.00000846599,0.00003547285,0.00001053404,0.00003203422,0.00003609293],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003549088,0.000126832,0.0001479847,0.0002039126,0.00002134878,0.000190664,0.00002536439,0.001035255,0.9875739,0.0004650237,0.0001786707,0.009676124],"study_design_scores_gemma":[0.0001494419,0.001876159,0.0006411048,0.0000105785,0.0000502579,0.0004435403,0.00001210684,0.00120124,0.9815409,0.00004116897,0.01401665,0.00001684556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8932626,0.01016867,0.08439532,0.0004468952,0.0001493097,0.001688527,0.001563573,0.0004681242,0.007856947],"genre_scores_gemma":[0.8851652,0.007497733,0.09549615,0.0003495684,0.00007552295,0.0007944623,0.002855988,0.0001027501,0.007662541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001216849,"threshold_uncertainty_score":0.004070818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03810206190235645,"score_gpt":0.3013347297914563,"score_spread":0.2632326678890999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}