{"id":"W2143951282","doi":"10.1016/j.cmet.2010.09.010","title":"Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress","year":2010,"lang":"en","type":"article","venue":"Cell Metabolism","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":465,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Windsor","funders":"Medical Research and Materiel Command; National Heart, Lung, and Blood Institute; National Institute on Aging; National Institutes of Health; National Institute of Allergy and Infectious Diseases; Fondation Leducq; National Institute of General Medical Sciences; American Heart Association","keywords":"Endoplasmic reticulum; CD36; Apoptosis; Unfolded protein response; Cell biology; TLR2; Macrophage; Chemistry; Biology; Medicine; Signal transduction; Biochemistry; Receptor; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000446695,0.0004334209,0.0005713222,0.0004455489,0.000383031,0.0003915941,0.000205856,0.0006099525,0.002386194],"category_scores_gemma":[0.000223779,0.0003430018,0.0005563489,0.0003317771,0.000327938,0.0004476155,0.0004487451,0.0008715205,0.001099188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004022505,"about_ca_system_score_gemma":0.0002814753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004706806,"about_ca_topic_score_gemma":0.0006317204,"domain_scores_codex":[0.9995073,0.0001050932,0.00004624211,0.00005905382,0.00009502337,0.0001872686],"domain_scores_gemma":[0.9998447,0.00001820428,0.00002802223,0.00003361141,0.00003938126,0.00003609591],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003639218,0.0001000961,0.0007963954,0.00008912807,0.00002182214,0.0002954531,0.00007126866,0.00005171784,0.9930477,0.0002025264,0.0001251247,0.001559643],"study_design_scores_gemma":[0.0002522099,0.0008179596,0.01722928,0.00001996356,0.00005422044,0.0009778036,0.0002495058,0.001266951,0.976278,0.0004346896,0.002405027,0.0000145002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932053,0.001922518,0.002519122,0.0002792548,0.00008989999,0.00004281147,0.0003821306,0.00005461417,0.0015044],"genre_scores_gemma":[0.9930307,0.0008585656,0.001582406,0.0001435823,0.00003827821,0.00008056837,0.0004239992,0.00001382119,0.003828174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002386194,"threshold_uncertainty_score":0.007982552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003442269891165635,"score_gpt":0.2070544176552667,"score_spread":0.2036121477641011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}