{"id":"W2143989967","doi":"10.1046/j.1365-2958.2000.01953.x","title":"Signature‐tagged and directed mutagenesis identify PABA synthetase as essential for <i>Aspergillus fumigatus</i> pathogenicity","year":2000,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nexen (Canada)","funders":"Medical Research Council; Wellcome Trust","keywords":"Biology; Aspergillus fumigatus; In vivo; Pathogen; Mutagenesis; Gene; Microbiology; Mutant; Aspergillus; Human pathogen; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001247736,0.0003346201,0.0002090459,0.0002034607,0.00009656559,0.0002602705,0.0001938999,0.000244724,0.0008097389],"category_scores_gemma":[0.0002588419,0.000144404,0.0002659421,0.0001726303,0.0001846461,0.00008963377,0.0001534939,0.0003274457,0.0004384652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002847158,"about_ca_system_score_gemma":0.0002919693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001529105,"about_ca_topic_score_gemma":0.001906288,"domain_scores_codex":[0.9998668,0.00002456816,0.00001997648,0.000020196,0.0000394825,0.00002895193],"domain_scores_gemma":[0.9998253,0.00004055562,0.00005533894,0.0000216083,0.00001894287,0.00003834226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005510153,0.00001223808,0.0002965578,0.000009819571,0.00000278486,0.00005657227,0.000005177295,0.00006523356,0.9987349,0.00006218506,0.00002170991,0.0006777223],"study_design_scores_gemma":[0.00001123333,0.00008688195,0.003591876,0.000002871941,0.00001057803,0.0004756457,0.00001626063,0.0009342177,0.9940863,0.00003659006,0.0007443671,0.000003210035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893706,0.0003188124,0.008469841,0.0001115479,0.00002368534,0.00003796844,0.0004097835,0.0001182981,0.001139403],"genre_scores_gemma":[0.9944029,0.0001528963,0.00405945,0.00004193927,0.000005256784,0.00001643672,0.0004944569,0.00004287074,0.0007838045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529105,"threshold_uncertainty_score":0.003040373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004626007937703585,"score_gpt":0.25883540430094,"score_spread":0.2542093963632364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}