{"id":"W2144007367","doi":"10.1074/jbc.m308914200","title":"The Crystal Structure of 1-D-myo-Inosityl 2-Acetamido-2-deoxy-α-D-glucopyranoside Deacetylase (MshB) from Mycobacterium tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"Mycobacterium tuberculosis; Lactate dehydrogenase; Zinc; Chemistry; Dehydrogenase; Hydrolase; Enzyme; Tuberculosis; Biochemistry; Microbiology; Molecular biology; Stereochemistry; Biology; Medicine; Pathology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003863839,0.0003886069,0.0005347454,0.00002638819,0.0001559196,0.00005910999,0.0005883441,0.0005331889,0.0001036356],"category_scores_gemma":[0.0007009741,0.0002220915,0.0004169906,0.0001894796,0.0005131125,0.00001127248,0.0001751077,0.0006057249,0.000001820677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004416688,"about_ca_system_score_gemma":0.0002025823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001453703,"about_ca_topic_score_gemma":0.000007679685,"domain_scores_codex":[0.9975574,0.0002459915,0.000729913,0.000465661,0.0004504643,0.0005505533],"domain_scores_gemma":[0.9979992,0.0001270124,0.0005563573,0.0005403744,0.0003664494,0.0004105881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001329132,0.0001816117,0.003155816,0.00005013756,0.0003856001,0.00007915271,0.000014103,0.00001375165,0.9941736,0.000008234309,0.0004658872,0.0001429057],"study_design_scores_gemma":[0.001409032,0.0006574778,0.000545884,0.00007541095,0.00009272515,0.0004103328,0.00007289278,0.000005969127,0.9908485,0.0002821476,0.005299353,0.0003002415],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953185,0.003655148,0.0001747305,0.0002266707,0.00005794954,0.000171062,0.0001475627,0.000008213057,0.0002401305],"genre_scores_gemma":[0.9975343,0.0008888167,0.0009142586,0.0001933903,0.0002333003,0.00000711856,0.00009059236,0.00003076766,0.0001074973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004833465,"threshold_uncertainty_score":0.905663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008455420761716587,"score_gpt":0.22970277706331,"score_spread":0.2212473563015934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}