{"id":"W2144007367","doi":"10.1074/jbc.m308914200","title":"The Crystal Structure of 1-D-myo-Inosityl 2-Acetamido-2-deoxy-α-D-glucopyranoside Deacetylase (MshB) from Mycobacterium tuberculosis Reveals a Zinc Hydrolase with a Lactate Dehydrogenase Fold","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canadian Institutes of Health Research; University of Alberta","funders":"","keywords":"Mycobacterium tuberculosis; Lactate dehydrogenase; Zinc; Chemistry; Dehydrogenase; Hydrolase; Enzyme; Tuberculosis; Biochemistry; Microbiology; Molecular biology; Stereochemistry; Biology; Medicine; Pathology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001386143,0.0003642078,0.0004903016,0.0001242108,0.000233539,0.0005591761,0.0005050758,0.0005523796,0.001131996],"category_scores_gemma":[0.000287312,0.0002499521,0.0001840887,0.0003872555,0.0002202652,0.0002598525,0.0002244941,0.0008520997,0.000596629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006384221,"about_ca_system_score_gemma":0.0004345147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002449962,"about_ca_topic_score_gemma":0.003107209,"domain_scores_codex":[0.9999024,0.000009703624,0.000005393144,0.00002396298,0.00004021979,0.0000183841],"domain_scores_gemma":[0.9998922,0.00001600741,0.00002600674,0.000004247971,0.00001699713,0.00004447348],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001748412,0.0004960488,0.01672987,0.001135298,0.000248867,0.002278362,0.0007609078,0.003454642,0.9273461,0.001381065,0.006633921,0.0377864],"study_design_scores_gemma":[0.00226405,0.002448366,0.2329737,0.0005389155,0.0007144517,0.01026051,0.002581294,0.05156196,0.4728284,0.001986141,0.2216217,0.0002206623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9745,0.01432377,0.003041803,0.001239073,0.0001934058,0.00005508502,0.001975348,0.0003222983,0.004349254],"genre_scores_gemma":[0.9668478,0.00766052,0.007860382,0.0004327779,0.00004309408,0.0000425317,0.00922587,0.00006545569,0.00782144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002449962,"threshold_uncertainty_score":0.004871428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008455420761716587,"score_gpt":0.22970277706331,"score_spread":0.2212473563015934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}