{"id":"W2144017148","doi":"10.1128/aac.00385-10","title":"NagZ Inactivation Prevents and Reverts β-Lactam Resistance, Driven by AmpD and PBP 4 Mutations, in <i>Pseudomonas aeruginosa</i>","year":2010,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Manitoba","funders":"Canadian Institutes of Health Research","keywords":"Pseudomonas aeruginosa; Mutant; Microbiology; Ceftazidime; Biology; Cephalosporin; Mutation; Antibacterial agent; Wild type; Penicillin binding proteins; Pseudomonadales; Pseudomonadaceae; Penicillin; Molecular biology; Antibiotics; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007139028,0.0005541148,0.0002723303,0.0001805425,0.0001022034,0.0003337538,0.0002846292,0.0002303586,0.0007855918],"category_scores_gemma":[0.0001676655,0.0002094673,0.0002543598,0.0001245508,0.0003139979,0.0001513815,0.0003180714,0.0005414498,0.0002698252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002651633,"about_ca_system_score_gemma":0.000213922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001262925,"about_ca_topic_score_gemma":0.0009513402,"domain_scores_codex":[0.9998239,0.00001849142,0.00001982928,0.00003296264,0.0000687193,0.00003615379],"domain_scores_gemma":[0.9998413,0.00002414337,0.00006443466,0.00002145659,0.00001529378,0.00003325306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005721087,0.00002414096,0.0001900863,0.00001480894,0.000005091471,0.00004940632,0.000008456473,0.00003434009,0.9987942,0.00003191613,0.0000117583,0.0007786246],"study_design_scores_gemma":[0.000009265684,0.0001873099,0.005329522,0.000003679611,0.00001414528,0.0002627213,0.00001978958,0.0005010522,0.9927049,0.00002012349,0.0009426306,0.000004723272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973243,0.0004197026,0.001181692,0.00005017549,0.00001476842,0.00001651459,0.0002084897,0.0001211658,0.0006631366],"genre_scores_gemma":[0.9964574,0.0003204387,0.001297131,0.00005029983,0.000008740257,0.00001988457,0.0004503228,0.00005164447,0.001344127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001262925,"threshold_uncertainty_score":0.002628028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003824448545396736,"score_gpt":0.2258829333407258,"score_spread":0.2220584847953291,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}