{"id":"W2144017255","doi":"10.1128/iai.68.11.6362-6369.2000","title":"Inverse Relation between Disease Severity and Expression of the Streptococcal Cysteine Protease, SpeB, among Clonal M1T1 Isolates Recovered from Invasive Group A Streptococcal Infection Cases","year":2000,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cysteine protease; Protease; Streptococcus; Biology; Group A; Microbiology; Proteases; Virulence; Streptococcus pyogenes; Enzyme; Virology; Bacteria; Biochemistry; Gene; Staphylococcus aureus; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001445656,0.0002646834,0.0003411809,0.000119192,0.0004671671,0.00004650037,0.00003699402,0.0002015632,0.0005955698],"category_scores_gemma":[0.0003006614,0.0001992985,0.000163484,0.0003035546,0.0002968844,0.0004730248,0.0000894459,0.000436743,0.000009059052],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000119192,"about_ca_system_score_gemma":0.00007435035,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01769798,"about_ca_topic_score_gemma":0.001171963,"domain_scores_codex":[0.9985281,0.0003428554,0.0004283814,0.0003450064,0.0001694643,0.0001861953],"domain_scores_gemma":[0.9987942,0.000248956,0.0002265627,0.0003837589,0.0001091163,0.0002374088],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004650466,0.0004794334,0.9824465,0.00008167941,0.0001187019,0.000004962035,0.0001597449,0.00001536311,0.008430403,0.000006658237,0.00005291972,0.007738581],"study_design_scores_gemma":[0.002399466,0.0005814653,0.9867759,0.0005086913,0.0003102274,0.00002573942,0.00003184386,0.0002344809,0.008130266,0.0004447583,0.0003803496,0.0001767908],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972634,0.00005612802,0.00004402148,0.00005116721,0.0001130562,0.001776447,0.0002498839,0.00008450356,0.0003614119],"genre_scores_gemma":[0.9988294,0.0002375679,0.00005890776,0.00002973323,0.000125146,0.0001645174,0.0003924086,0.00001912226,0.0001431814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01652602,"threshold_uncertainty_score":0.9888433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161868160461943,"score_gpt":0.262555845270506,"score_spread":0.2409371636658866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}