{"id":"W2144017255","doi":"10.1128/iai.68.11.6362-6369.2000","title":"Inverse Relation between Disease Severity and Expression of the Streptococcal Cysteine Protease, SpeB, among Clonal M1T1 Isolates Recovered from Invasive Group A Streptococcal Infection Cases","year":2000,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Cysteine protease; Protease; Streptococcus; Biology; Group A; Microbiology; Proteases; Virulence; Streptococcus pyogenes; Enzyme; Virology; Bacteria; Biochemistry; Gene; Staphylococcus aureus; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002208855,0.0002507996,0.0002231558,0.0006931762,0.0002803721,0.0003530406,0.0001414065,0.0003593548,0.001096253],"category_scores_gemma":[0.001910758,0.0001802576,0.0001471027,0.0002944233,0.0002684857,0.0002375981,0.0002723675,0.0003898686,0.0001729683],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001352729,"about_ca_system_score_gemma":0.00008858047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005991477,"about_ca_topic_score_gemma":0.0005324746,"domain_scores_codex":[0.9997049,0.00005414544,0.00004815427,0.00007905449,0.00006327726,0.00005039474],"domain_scores_gemma":[0.9986899,0.0003300575,0.0004901679,0.00007198453,0.0001384223,0.0002793615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003230761,0.00003893752,0.9773297,0.00001389923,0.00003085183,0.0004775896,0.0001821704,0.00004119511,0.0196087,0.00001542823,0.00004810761,0.001890364],"study_design_scores_gemma":[0.000004412823,0.0001953121,0.9964213,0.000002606314,0.00001465497,0.002021075,0.0001483036,0.0001442413,0.0009441248,0.00001611234,0.00008495656,0.000002849282],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9998062,0.00005639264,0.00003226381,0.000005432894,8.97933e-7,0.000001399192,0.00001374044,0.000001156588,0.00008252817],"genre_scores_gemma":[0.999795,0.00003264373,0.00004472374,0.000006123299,0.000004122272,0.000001768479,0.00005423311,0.000001025093,0.00006036228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001096253,"threshold_uncertainty_score":0.003667295,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02161868160461943,"score_gpt":0.262555845270506,"score_spread":0.2409371636658866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}