{"id":"W2144083605","doi":"10.1007/s10495-006-8205-1","title":"Downregulation of the PI3K/Akt survival pathway in cells with deregulated expression of c-Myc","year":2006,"lang":"en","type":"article","venue":"APOPTOSIS","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"","keywords":"Downregulation and upregulation; PI3K/AKT/mTOR pathway; Apoptosis; Cell biology; Protein kinase B; Chemistry; Expression (computer science); Cancer research; Biology; Gene; Computer science; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002055667,0.0003605254,0.0004021658,0.0003801356,0.0002680782,0.0005440403,0.0002941501,0.0003215607,0.001204257],"category_scores_gemma":[0.0001681646,0.0002180952,0.0003700579,0.0003968104,0.0003682056,0.0002775161,0.0001845247,0.0009604774,0.000363674],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005475487,"about_ca_system_score_gemma":0.0003501786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001075489,"about_ca_topic_score_gemma":0.001130157,"domain_scores_codex":[0.9996922,0.00004182569,0.00004375944,0.00004559332,0.00007534271,0.0001013693],"domain_scores_gemma":[0.9998453,0.0000395591,0.00002907912,0.00003336068,0.00001530136,0.00003750971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002940202,0.00007249941,0.0002137161,0.00001839089,0.000009659629,0.00007909682,0.00001368427,0.00009605985,0.9981542,0.0002456364,0.00005902221,0.0007440323],"study_design_scores_gemma":[0.00003183615,0.0002163725,0.002389152,0.000001950174,0.00001788749,0.000216961,0.00002576154,0.00139072,0.9943189,0.0000448069,0.001341868,0.00000373979],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964046,0.0007624635,0.001141666,0.0001132363,0.00006093844,0.00002113483,0.0003885611,0.000067218,0.001040209],"genre_scores_gemma":[0.9966846,0.0003362195,0.0008921556,0.00003342348,0.00001027118,0.00003316231,0.0004773278,0.00001512275,0.001517862],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001204257,"threshold_uncertainty_score":0.004028618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004298186233264762,"score_gpt":0.1971496355269066,"score_spread":0.1928514492936418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}