{"id":"W2144087336","doi":"10.1093/hmg/ddn184","title":"A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"National Center for Research Resources; Reumatikerförbundet; Knut och Alice Wallenbergs Stiftelse; Uppsala Universitet; Akademiska Sjukhuset; Vetenskapsrådet; Karolinska Institutet; Lupus Research Alliance; Genome Canada","keywords":"IRF5; Haplotype; Single-nucleotide polymorphism; STAT4; Biology; Allele; Immunology; SNP; Allele frequency; Genetics; Genotype; Interferon regulatory factors; Gene; Transcription factor; stat","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002445427,0.0007618633,0.0004991276,0.0007109559,0.000348561,0.0003080087,0.0002005711,0.0006100519,0.00659733],"category_scores_gemma":[0.000778656,0.0002027272,0.0008273855,0.0005179049,0.0002853487,0.0001168287,0.0002801466,0.000386581,0.0005490782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001482066,"about_ca_system_score_gemma":0.0001791774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007404474,"about_ca_topic_score_gemma":0.001136969,"domain_scores_codex":[0.9995773,0.0001322555,0.00004740555,0.0001415779,0.0000500753,0.00005136635],"domain_scores_gemma":[0.9990678,0.0003723089,0.0002954091,0.00007294273,0.00003371446,0.0001578214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005266177,0.0003013457,0.7189137,0.0001565889,0.001082084,0.004775085,0.0003560858,0.0007445369,0.2541433,0.0005415882,0.0008240745,0.01289542],"study_design_scores_gemma":[0.0001964528,0.0008863645,0.9700804,0.00004704886,0.0006982406,0.015243,0.0001961994,0.002423853,0.008187582,0.0006708014,0.001333984,0.00003613438],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984269,0.0001670214,0.0007661459,0.0000405237,0.0000152966,0.000004805179,0.0002217958,0.00002800134,0.0003294549],"genre_scores_gemma":[0.998736,0.00004158687,0.0004856467,0.00003227756,0.00001864677,0.000006079674,0.0003235392,0.000009774453,0.0003463707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00659733,"threshold_uncertainty_score":0.02207029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130748039919851,"score_gpt":0.2645987470099302,"score_spread":0.2532912666107317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}