{"id":"W2144087336","doi":"10.1093/hmg/ddn184","title":"A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":214,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University and Génome Québec Innovation Centre","funders":"National Center for Research Resources; Reumatikerförbundet; Knut och Alice Wallenbergs Stiftelse; Uppsala Universitet; Akademiska Sjukhuset; Vetenskapsrådet; Karolinska Institutet; Lupus Research Alliance; Genome Canada","keywords":"IRF5; Haplotype; Single-nucleotide polymorphism; STAT4; Biology; Allele; Immunology; SNP; Allele frequency; Genetics; Genotype; Interferon regulatory factors; Gene; Transcription factor; stat","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002851762,0.0004102592,0.001063413,0.0002521776,0.0001603409,0.000015602,0.0002027334,0.0001607772,0.00002046816],"category_scores_gemma":[0.0001479911,0.0003080736,0.0001441635,0.0002377863,0.000604384,0.00003852821,0.00008846019,0.0002727617,0.000003000912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005632732,"about_ca_system_score_gemma":0.0002069017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001304797,"about_ca_topic_score_gemma":0.00004134684,"domain_scores_codex":[0.9972962,0.0002179771,0.0005870301,0.0005914122,0.0008238551,0.0004834873],"domain_scores_gemma":[0.9972011,0.0004726214,0.0006630098,0.000819155,0.0006200814,0.0002240023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001375622,0.0003222123,0.799118,0.004488226,0.001403764,0.0004497733,0.005773214,0.0002789029,0.1856258,0.000138079,0.000854325,0.0001721346],"study_design_scores_gemma":[0.05933373,0.01912277,0.06581417,0.01400604,0.004657424,0.05476305,0.0046953,0.00736374,0.7671713,0.000884779,0.0003291261,0.001858537],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848193,0.006853753,0.005241915,0.000008128184,0.0000351704,0.002623471,0.000256143,0.0000441184,0.0001180141],"genre_scores_gemma":[0.9935419,0.001753565,0.004115044,0.00002029873,0.00003866191,0.000147499,0.00004702451,0.0001472768,0.0001887058],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7333038,"threshold_uncertainty_score":0.9999371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01130748039919851,"score_gpt":0.2645987470099302,"score_spread":0.2532912666107317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}