{"id":"W2144110603","doi":"10.1074/jbc.m110871200","title":"Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":156,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto Western Hospital; Occupational Cancer Research Centre; University of Toronto","funders":"National Institutes of Health; Alzheimer's Society; Canadian Institutes of Health Research; March of Dimes Foundation","keywords":"Nicastrin; Presenilin; Golgi apparatus; Cell biology; Endoplasmic reticulum; Amyloid precursor protein; Biology; Amyloid precursor protein secretase; Ectodomain; Immunoprecipitation; Effector; Chemistry; Biochemistry; Alzheimer's disease; Internal medicine; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006364024,0.0001496579,0.0001470043,0.0001107143,0.000131508,0.0002936902,0.00008815501,0.0001163482,0.0008365797],"category_scores_gemma":[0.0001896566,0.0001006536,0.00008727591,0.0001008288,0.00008766988,0.0002114754,0.0001649742,0.0001770619,0.0002150579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003039478,"about_ca_system_score_gemma":0.0001075289,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001111757,"about_ca_topic_score_gemma":0.001561119,"domain_scores_codex":[0.9999453,0.000008599731,0.000003683941,0.000009109932,0.00001401482,0.00001921362],"domain_scores_gemma":[0.9999347,0.000009546898,0.00001283545,0.000006055364,0.00001545417,0.00002129063],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009338499,0.000003872816,0.000284371,0.000009581601,0.000002278553,0.00004489023,0.00002271897,0.00003645233,0.9987897,0.00008317715,0.00002232802,0.000607255],"study_design_scores_gemma":[0.00001507444,0.0001721662,0.07019092,0.000009598486,0.00002774134,0.0007525629,0.0001943276,0.002455327,0.9210274,0.0002424878,0.004901986,0.00001044386],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984173,0.0006426251,0.0003179885,0.00002163444,0.00000317866,0.000003278489,0.00003648846,0.000007862713,0.0005496746],"genre_scores_gemma":[0.9975339,0.0006253987,0.0003891508,0.00002393371,0.000004535226,0.000006179104,0.0001617239,0.000008591208,0.001246532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001111757,"threshold_uncertainty_score":0.002798617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06407722803840858,"score_gpt":0.3178529426863945,"score_spread":0.2537757146479859,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}