{"id":"W2144120657","doi":"10.1038/nature15515","title":"Hallmarks of pluripotency","year":2015,"lang":"en","type":"review","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":405,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Howard Hughes Medical Institute","keywords":"Induced pluripotent stem cell; Biology; Stem cell; Epigenetics; Computational biology; Embryonic stem cell; Cellular differentiation; Cell biology; Cell potency; Functional genomics; Genomics; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0004132021,0.0003095495,0.0009178583,0.0001232027,0.00002201473,0.00001108222,0.0007105842,0.00489514,0.00003612989],"category_scores_gemma":[0.0001932342,0.0002397088,0.0004648669,0.0002019805,0.00007331443,0.000001402308,0.0003442967,0.002140064,0.00004906285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003407188,"about_ca_system_score_gemma":0.0006761386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003468742,"about_ca_topic_score_gemma":0.000004002357,"domain_scores_codex":[0.9982777,0.0001609908,0.0003714756,0.0004715398,0.0004307439,0.0002875961],"domain_scores_gemma":[0.9986095,0.00001573628,0.0002361771,0.0007356049,0.0002713668,0.0001316493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001731998,0.00006127668,0.00000138155,0.01222609,0.0002417548,0.00002020797,0.000004182222,5.377576e-7,0.0002872126,0.00004597239,0.06532977,0.9217643],"study_design_scores_gemma":[0.0001270105,0.00009204606,6.375133e-7,0.001300317,0.0001185408,0.00004173259,0.000001964489,5.462358e-7,0.0001964882,0.00001903568,0.9978818,0.0002198908],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000005318381,0.987985,0.000007494157,0.00001967109,0.0002761839,0.000423426,0.000141741,0.000007476679,0.0111337],"genre_scores_gemma":[0.00002480252,0.9920788,0.0001893289,0.00003274167,0.0003788458,0.00002674094,0.0009664739,0.000056824,0.006245475],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.932552,"threshold_uncertainty_score":0.9963967,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578790651284873,"score_gpt":0.3503307312070522,"score_spread":0.3245428246942035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}