{"id":"W2144120657","doi":"10.1038/nature15515","title":"Hallmarks of pluripotency","year":2015,"lang":"en","type":"review","venue":"Nature","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":405,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"Howard Hughes Medical Institute","keywords":"Induced pluripotent stem cell; Biology; Stem cell; Epigenetics; Computational biology; Embryonic stem cell; Cellular differentiation; Cell biology; Cell potency; Functional genomics; Genomics; Genetics; Gene; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007624878,0.0009720493,0.001176137,0.001521119,0.0003420731,0.001398827,0.001182334,0.001191684,0.003215073],"category_scores_gemma":[0.001172103,0.0002675325,0.0003461927,0.00164091,0.001367646,0.001708,0.001116924,0.002909551,0.001964326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008704288,"about_ca_system_score_gemma":0.001338347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008440076,"about_ca_topic_score_gemma":0.001580303,"domain_scores_codex":[0.9997399,0.00004325813,0.00004035171,0.00004137549,0.0001034972,0.00003151087],"domain_scores_gemma":[0.999643,0.0001669664,0.00004819594,0.00001527702,0.0000760726,0.0000506291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000545432,0.00002271415,0.0002416215,0.006424153,0.00003506086,0.0003209224,0.00005491409,0.000302844,0.002897547,0.01856745,0.06540077,0.9056775],"study_design_scores_gemma":[0.00000644966,0.00001570048,0.0002512898,0.0009957757,0.00002556691,0.0006386038,0.00003494816,0.00004469145,0.0005724077,0.00595636,0.9914477,0.00001052371],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001371989,0.9927202,0.0007990991,0.001283041,0.001439501,0.000008938724,0.00005708393,0.00002740777,0.003527555],"genre_scores_gemma":[0.001806886,0.9933497,0.0005815927,0.001235727,0.0008326654,0.00001606909,0.00009596249,0.000004928354,0.0020764],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003215073,"threshold_uncertainty_score":0.01075548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02578790651284873,"score_gpt":0.3503307312070522,"score_spread":0.3245428246942035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}