{"id":"W2144123665","doi":"10.1158/0008-5472.can-05-4076","title":"HER-2/neu Status Is a Determinant of Mammary Aromatase Activity <i>In vivo</i>: Evidence for a Cyclooxygenase-2-Dependent Mechanism","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; Medical College of Wisconsin; National Institutes of Health; Botwinick-Wolfensohn Foundation; Breast Cancer Alliance; Breast Cancer Research Foundation","keywords":"Aromatase; Endocrinology; Internal medicine; Estrogen; Cyclooxygenase; In vivo; Prostaglandin; Chemistry; Prostaglandin E; Biology; Cancer research; Cancer; Enzyme; Breast cancer; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006400803,0.0001467574,0.0001938578,0.0001153838,0.00008181481,0.00002382734,0.0002784784,0.0002098015,0.00001643554],"category_scores_gemma":[0.0000840922,0.0001322523,0.0001060926,0.0001945807,0.00009529671,0.00001234247,0.0001882299,0.0002211755,0.000003075821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008712852,"about_ca_system_score_gemma":0.0004127911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001821066,"about_ca_topic_score_gemma":0.0003303327,"domain_scores_codex":[0.9982002,0.0001727685,0.0002013031,0.0004746226,0.0003349408,0.0006161229],"domain_scores_gemma":[0.9991298,0.00009310782,0.00006960508,0.0004538372,0.0001413271,0.0001123771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006360628,0.0001391205,0.000530126,0.000166731,0.00002781639,0.00003871806,0.0000311321,0.00002020703,0.9929177,0.0000961613,0.002639776,0.002756457],"study_design_scores_gemma":[0.0008608261,0.0005286303,0.0006307864,0.0001395164,0.000009974481,0.00000852087,0.00001833378,0.0001931321,0.9953926,0.0004309811,0.001639072,0.0001475994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99151,0.006687191,0.0004701737,0.0001618928,0.00007755536,0.0007586564,0.000212129,0.00000730714,0.0001150886],"genre_scores_gemma":[0.9955318,0.002839047,0.0002306875,0.00003701869,0.0001085249,0.000431485,0.00001759985,0.00002689588,0.0007769496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004021786,"threshold_uncertainty_score":0.5393093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04374078491200886,"score_gpt":0.3794387762988127,"score_spread":0.3356979913868039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}