{"id":"W2144123665","doi":"10.1158/0008-5472.can-05-4076","title":"HER-2/neu Status Is a Determinant of Mammary Aromatase Activity <i>In vivo</i>: Evidence for a Cyclooxygenase-2-Dependent Mechanism","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Heart, Lung, and Blood Institute; National Cancer Institute; Medical College of Wisconsin; National Institutes of Health; Botwinick-Wolfensohn Foundation; Breast Cancer Alliance; Breast Cancer Research Foundation","keywords":"Aromatase; Endocrinology; Internal medicine; Estrogen; Cyclooxygenase; In vivo; Prostaglandin; Chemistry; Prostaglandin E; Biology; Cancer research; Cancer; Enzyme; Breast cancer; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001862886,0.0002609536,0.0002115999,0.0003065369,0.0001021348,0.0003252497,0.0001119365,0.0002186163,0.001776327],"category_scores_gemma":[0.0002443465,0.0001531528,0.0001646548,0.0001735815,0.0001991507,0.0002174621,0.0001462437,0.0003677338,0.0003388912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002195888,"about_ca_system_score_gemma":0.0001116441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004097039,"about_ca_topic_score_gemma":0.0005830636,"domain_scores_codex":[0.9998784,0.0000239697,0.000008782961,0.00002117795,0.00003448968,0.00003313625],"domain_scores_gemma":[0.9997526,0.00005185707,0.00008037496,0.00002393505,0.0000265957,0.0000647606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005988179,0.00007001531,0.006955269,0.00003207116,0.00001016118,0.0001315827,0.00001337235,0.0000276131,0.9903847,0.00005501202,0.00004530092,0.001676119],"study_design_scores_gemma":[0.00003098992,0.00112981,0.1970175,0.00001159319,0.00005676041,0.001642088,0.00009224025,0.0009973593,0.7966455,0.0001584312,0.002206065,0.00001163812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954792,0.001697042,0.001042317,0.00007688989,0.0000223399,0.00002500576,0.0003741535,0.00002601904,0.001257025],"genre_scores_gemma":[0.9967149,0.001022132,0.0005073213,0.00003359265,0.00001496402,0.00002277571,0.0004528167,0.000006312499,0.001225112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001776327,"threshold_uncertainty_score":0.005942464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04374078491200886,"score_gpt":0.3794387762988127,"score_spread":0.3356979913868039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}