{"id":"W2144136328","doi":"10.1310/hct1105-312","title":"A Randomized, Placebo-Controlled Trial of Abacavir Intensification in HIV-1–Infected Adults With Virologic Suppression on a Protease Inhibitor–Containing Regimen","year":2010,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; College of Medicine, University of Cincinnati; University at Buffalo; University of California, San Diego; BioCryst; Deutsches Krebsforschungszentrum; International AIDS Society; University of Cincinnati; Johns Hopkins University; ACT Government; Georgia Clinical and Translational Science Alliance; Tulane University; University of Minnesota; University of Rochester; University of Miami; Northwestern University; York University; Bristol-Myers Squibb; University of Pennsylvania; Gilead Sciences; Vanderbilt University; Emory University; University of Nebraska Medical Center; National Institutes of Health; Ohio State University; University of Southern California; GlaxoSmithKline","keywords":"Medicine; Abacavir; Zidovudine; Regimen; Internal medicine; Lamivudine; Clinical endpoint; Placebo; Viral load; Indinavir; Population; Efavirenz; Discontinuation; Adverse effect; Gastroenterology; Randomized controlled trial; Immunology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Viral disease; Virus; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002076561,0.001884017,0.004260548,0.0005837897,0.0007275556,0.001419706,0.001184083,0.002688282,0.01022291],"category_scores_gemma":[0.00295745,0.0009489688,0.001898804,0.0004269795,0.001678214,0.00122319,0.0005478815,0.003866172,0.001260684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007457724,"about_ca_system_score_gemma":0.001363518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001220454,"about_ca_topic_score_gemma":0.002121684,"domain_scores_codex":[0.9986517,0.0007838696,0.000096193,0.0002290623,0.00008645023,0.0001527913],"domain_scores_gemma":[0.9982439,0.0005811612,0.0003719084,0.0001590067,0.0001357602,0.0005082178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.99116,0.004087322,0.0001377334,0.0002661976,0.0003261497,0.00001508062,0.00002137925,0.00005870277,0.0005574388,0.00004323257,0.0001783007,0.00314847],"study_design_scores_gemma":[0.9819748,0.01726305,0.0003353001,0.00001437234,0.0001141901,0.000007034631,0.00000632212,0.00009277547,0.00005538672,0.00003477219,0.00009842792,0.000003632164],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800878,0.004315723,0.0005665979,0.0008718938,0.001771668,0.008651124,0.0008272219,0.0001449707,0.002762921],"genre_scores_gemma":[0.9833013,0.002184738,0.001843782,0.001329457,0.001062064,0.007126288,0.0007150077,0.00001902317,0.002418377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01022291,"threshold_uncertainty_score":0.03419906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06691439298854879,"score_gpt":0.3846769090118663,"score_spread":0.3177625160233175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}