{"id":"W2144136328","doi":"10.1310/hct1105-312","title":"A Randomized, Placebo-Controlled Trial of Abacavir Intensification in HIV-1–Infected Adults With Virologic Suppression on a Protease Inhibitor–Containing Regimen","year":2010,"lang":"en","type":"article","venue":"HIV Clinical Trials","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; College of Medicine, University of Cincinnati; University at Buffalo; University of California, San Diego; BioCryst; Deutsches Krebsforschungszentrum; International AIDS Society; University of Cincinnati; Johns Hopkins University; ACT Government; Georgia Clinical and Translational Science Alliance; Tulane University; University of Minnesota; University of Rochester; University of Miami; Northwestern University; York University; Bristol-Myers Squibb; University of Pennsylvania; Gilead Sciences; Vanderbilt University; Emory University; University of Nebraska Medical Center; National Institutes of Health; Ohio State University; University of Southern California; GlaxoSmithKline","keywords":"Medicine; Abacavir; Zidovudine; Regimen; Internal medicine; Lamivudine; Clinical endpoint; Placebo; Viral load; Indinavir; Population; Efavirenz; Discontinuation; Adverse effect; Gastroenterology; Randomized controlled trial; Immunology; Human immunodeficiency virus (HIV); Antiretroviral therapy; Viral disease; Virus; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01766849,0.000377157,0.004103484,0.000330632,0.00005658979,0.00002091651,0.0001239122,0.0004788631,0.000130781],"category_scores_gemma":[0.05392823,0.0002079982,0.0007097296,0.0002553069,0.0002652789,0.00008248122,0.00004288872,0.000863389,0.00008936341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000496254,"about_ca_system_score_gemma":0.0003685393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001360255,"about_ca_topic_score_gemma":0.00001663168,"domain_scores_codex":[0.9912134,0.003747973,0.003521409,0.0006738525,0.0005082809,0.0003351199],"domain_scores_gemma":[0.9833497,0.01387857,0.00167161,0.0005840738,0.0002511042,0.0002648828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9889856,0.002700801,0.002488853,0.00003432045,0.0004155121,0.00007108256,0.0004188937,0.000002741076,0.001174464,0.0001473526,0.0004591481,0.003101215],"study_design_scores_gemma":[0.9913904,0.002936139,0.0009821963,0.0009122489,0.0006707912,0.000007899755,0.0001267402,0.000563856,0.001826799,0.0001063084,0.0002650006,0.0002115904],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735858,0.00002221143,0.00007690061,0.003842637,0.0005273025,0.02020985,0.00001159702,0.00008788593,0.001635779],"genre_scores_gemma":[0.9929525,0.00005492997,0.001826976,0.0001501664,0.000610562,0.00276321,0.0001434211,0.00003368322,0.001464609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03625973,"threshold_uncertainty_score":0.9540409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06691439298854879,"score_gpt":0.3846769090118663,"score_spread":0.3177625160233175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}