{"id":"W2144139389","doi":"10.1523/jneurosci.23-10-04081.2003","title":"Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease","year":2003,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":274,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Carleton University; Merck Canada Inc. (Canada)","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; Canadian Institutes of Health Research; National Institutes of Health; Ontario Neurotrauma Foundation; Wellcome Trust; Parkinson's Foundation; Muscular Dystrophy Association; Parkinson's Disease Foundation","keywords":"MPTP; Neuroscience; Parkinson's disease; Disease; Calpain; Psychology; Medicine; Biology; Internal medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001999863,0.0000559782,0.00008280117,0.00007565688,0.00002213357,0.000006774516,0.00005136902,0.00003244181,9.445621e-7],"category_scores_gemma":[0.00009903119,0.00004977112,0.00004024574,0.00007823243,0.00009352312,0.00002041468,0.00001753153,0.00005708708,2.366395e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005828713,"about_ca_system_score_gemma":0.0000932668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001425019,"about_ca_topic_score_gemma":0.000002997725,"domain_scores_codex":[0.9993275,0.00008782018,0.000234883,0.0001200429,0.0001539607,0.00007574042],"domain_scores_gemma":[0.9995618,0.000003542367,0.0002001781,0.00008271173,0.0000711945,0.0000805329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009251337,0.0002352049,0.0178772,0.00001012406,4.016954e-7,0.000001753438,0.00001981376,0.006497685,0.9749977,0.00002504917,0.000007495318,0.0002350739],"study_design_scores_gemma":[0.001078843,0.001160187,0.2160015,0.00003899605,0.00001935882,0.00003052398,0.00003343996,0.00978821,0.7713406,0.0001491811,0.0002374522,0.0001217268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974458,0.0000506412,0.002333165,0.0000176176,0.00006777449,0.00006900405,0.00001031168,8.032653e-7,0.000004840486],"genre_scores_gemma":[0.9996324,0.00003985089,0.0002040057,0.00005662291,0.000009197408,0.000001028111,0.000001878491,0.000004434498,0.00005063213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2036571,"threshold_uncertainty_score":0.2029607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02815561693119356,"score_gpt":0.2773215293765638,"score_spread":0.2491659124453703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}